Publication result detail

Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment

JUŘÍKOVÁ, L.; MASÁROVÁ, L.; PANOVSKÝ, R.; PEŠL, M.; REVENDOVÁ, K.; VOLNÝ, O.; FEITOVÁ, V.; HOLEČEK, T.; KINCL, V.; DANHOFER, P.; VOHÁŇKA, S.; HABERLOVÁ, J.; PODOLSKÁ, K.

Original Title

Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment

English Title

Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment

Type

WoS Article

Original Abstract

In this prospective study involving 37 Duchenne muscular dystrophy (DMD) patients aged 8-18 years and older, we examined the impact of neurological and cardiac factors on quality of life (QoL). Our findings revealed a negative correlation between upper limb movement and overall mobility, self-service, and usual activities. Ambulatory and non-ambulatory DMD patients showed significant differences in mobility-related parameters. Cardiac evaluations demonstrated associations between mitral annular plane systolic excursion (MAPSE) and mobility-related aspects. The PEDSQL 3.0 neuromuscular model questionnaire further highlighted age-related and movement-related correlations with QoL. The loss of ambulatory status and reduced upper limb movement were negatively associated with QoL, while upper limb movement positively correlated with septal MAPSE. However, no significant associations were found between MAPSE and anxiety/depression. These findings underscore the multifaceted impact of DMD on QoL and emphasize the importance of considering both neurological and cardiac factors in comprehensive patient care.

English abstract

In this prospective study involving 37 Duchenne muscular dystrophy (DMD) patients aged 8-18 years and older, we examined the impact of neurological and cardiac factors on quality of life (QoL). Our findings revealed a negative correlation between upper limb movement and overall mobility, self-service, and usual activities. Ambulatory and non-ambulatory DMD patients showed significant differences in mobility-related parameters. Cardiac evaluations demonstrated associations between mitral annular plane systolic excursion (MAPSE) and mobility-related aspects. The PEDSQL 3.0 neuromuscular model questionnaire further highlighted age-related and movement-related correlations with QoL. The loss of ambulatory status and reduced upper limb movement were negatively associated with QoL, while upper limb movement positively correlated with septal MAPSE. However, no significant associations were found between MAPSE and anxiety/depression. These findings underscore the multifaceted impact of DMD on QoL and emphasize the importance of considering both neurological and cardiac factors in comprehensive patient care.

Keywords

quality of life; Duchenne muscular dystrophy; cardiac magnetic resonance; neurological status; cardiac impairment

Key words in English

quality of life; Duchenne muscular dystrophy; cardiac magnetic resonance; neurological status; cardiac impairment

Authors

JUŘÍKOVÁ, L.; MASÁROVÁ, L.; PANOVSKÝ, R.; PEŠL, M.; REVENDOVÁ, K.; VOLNÝ, O.; FEITOVÁ, V.; HOLEČEK, T.; KINCL, V.; DANHOFER, P.; VOHÁŇKA, S.; HABERLOVÁ, J.; PODOLSKÁ, K.

RIV year

2025

Released

08.02.2024

Publisher

FRONTIERS MEDIA SA

Location

LAUSANNE

ISBN

1664-2295

Periodical

Frontiers in Neurology

Volume

15

Number

2

State

Swiss Confederation

Pages from

1

Pages to

11

Pages count

11

URL

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360385/full

Full text in the Digital Library

http://hdl.handle.net/11012/245500

BibTex

@article{BUT188247,
  author="Lenka {Juříková} and Lucia {Masárová} and Roman {Panovský} and Martin {Pešl} and Kamila {Žondra Revendová} and Ondřej {Volný} and Věra {Feitová} and Tomáš {Holeček} and Vladimír {Kincl} and Pavlína {Danhofer} and Stanislav {Voháňka} and Jana {Haberlová} and Karolína {Podolská}",
  title="Decreased quality of life in Duchenne muscular disease patients related to functional neurological and cardiac impairment",
  journal="Frontiers in Neurology",
  year="2024",
  volume="15",
  number="2",
  pages="1--11",
  doi="10.3389/fneur.2024.1360385",
  issn="1664-2295",
  url="https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1360385/full"
}

Documents

fneur-15-1360385