Publication detail

Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives

Kumar, Rahul Thakur, Amit K. Banerjee, Nilanjana Kumar, Ashutosh Gaurav, Gajendra Kumar Arya, Raj Kumar

Original Title

Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives

Type

journal article in Web of Science

Language

English

Original Abstract

The present work reviews the liquid antisolvent crystallization (LASC) to prepare the nanoparticle of pharmaceutical compounds to enhance their solubility, dissolution rate, and bioavailability. The application of ultrasound and additives is discussed to prepare the particles with narrow size distribution. The use of ionic liquid as an alternative to conventional organic solvent is presented. Herbal compounds, also known for low aqueous solubility and limited clinical application, have been crystalized by LASC and discussed here. The particle characteristics such as particle size and particle size distribution are interpreted in terms of supersaturation, nucleation, and growth phenomena. To overcome the disadvantage of batch crystallization, the scientific literature on continuous flow reactors is also reviewed. LASC in a microfluidic device is emerging as a promising technique. The different design of the microfluidic device and their application in LASC are discussed. The combination of the LASC technique with traditional techniques such as high-pressure homogenization and spray drying is presented. A comparison of product characteristics prepared by LASC and the supercritical CO2 antisolvent method is discussed to show that LASC is an attractive and inexpensive alternative for nanoparticle preparation. One of the major strengths of this paper is a discussion on less-explored applications of LASC in pharmaceutical research to attract the attention of future researchers.

Keywords

Antisolvent; Bioavailability; Crystallization; Microfluidic; Nanoparticle

Authors

Kumar, Rahul; Thakur, Amit K.; Banerjee, Nilanjana; Kumar, Ashutosh; Gaurav, Gajendra Kumar; Arya, Raj Kumar

Released

1. 2. 2023

Publisher

SPRINGER HEIDELBERGTIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY

Location

SPRINGER HEIDELBERGTIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY

ISBN

2190-393X

Periodical

Drug Delivery and Translational Research

Year of study

2

Number

13

State

Federal Republic of Germany

Pages from

400

Pages to

418

Pages count

19

URL

https://link.springer.com/article/10.1007/s13346-022-01219-1

BibTex

@article{BUT187697,
  author="Kumar, Rahul and Thakur, Amit K. and Banerjee, Nilanjana and Kumar, Ashutosh and Gaurav, Gajendra Kumar and Arya, Raj Kumar",
  title="Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives",
  journal="Drug Delivery and Translational Research",
  year="2023",
  volume="2",
  number="13",
  pages="400--418",
  doi="10.1007/s13346-022-01219-1",
  issn="2190-393X",
  url="https://link.springer.com/article/10.1007/s13346-022-01219-1"
}