IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS

IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS

Paper in proceedings outside WoS and Scopus

Although preventable, hypertension and hypertensive renal disease remain one of the major global risk factors for cardiovascular diseases, especially in the developed world [1]. Hypertension is defined as a chronically increased blood pressure (BP) above 140/90 mmHg and is related to an increase in peripheral resistance and decrease in arterial distensibility [2], similarly to an aging [1]. Available evidence confirms the ability of all five basic groups of antihypertensives to decrease arterial stiffness and consequently the BP in the long-term application [3]. Although proper treatment of hypertension attenuates its influence, the mechanisms by which hypertension accelerates atherosclerosis are poorly understood [4]. It is known that flow waveform for older subjects differs substantially from the young one mainly due to elevated arterial stiffness and consequently early wave reflection [5]. Moreover, the decreasing arterial stiffness via proper treatment of hypertension shifts the shape of the flow waveform to a young and healthy one [6]. Since arterial stiffness can be lowered through long-term application of antihypertensives, benefits of medical therapy could be not only in lowering the BP and peripheral resistance but also in improving the hemodynamic conditions.

Although preventable, hypertension and hypertensive renal disease remain one of the major global risk factors for cardiovascular diseases, especially in the developed world [1]. Hypertension is defined as a chronically increased blood pressure (BP) above 140/90 mmHg and is related to an increase in peripheral resistance and decrease in arterial distensibility [2], similarly to an aging [1]. Available evidence confirms the ability of all five basic groups of antihypertensives to decrease arterial stiffness and consequently the BP in the long-term application [3]. Although proper treatment of hypertension attenuates its influence, the mechanisms by which hypertension accelerates atherosclerosis are poorly understood [4]. It is known that flow waveform for older subjects differs substantially from the young one mainly due to elevated arterial stiffness and consequently early wave reflection [5]. Moreover, the decreasing arterial stiffness via proper treatment of hypertension shifts the shape of the flow waveform to a young and healthy one [6]. Since arterial stiffness can be lowered through long-term application of antihypertensives, benefits of medical therapy could be not only in lowering the BP and peripheral resistance but also in improving the hemodynamic conditions.

HEMODYNAMICAL SIMULATIONS; ANTIHYPERTENSIVE DRUGS

HEMODYNAMICAL SIMULATIONS; ANTIHYPERTENSIVE DRUGS

JAGOŠ, J.; KOHÚT, J.; NOVOTNÝ, T.; KŘIVKA, T.; HÁJEK, P.; FORMÁNEK, M.; BURŠA, J.

09.07.2023

Maastricht

ESB 2023 BOOK OF ABSTRACTS

1

https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf