Publication result detail

MECHANICAL RESPONSE OF ENDOTHELIAL CELLS TO SHEAR FLOW AS POSSIBLE MARKER IN DEVELOPMENT OF ATHEROSCLEROSIS

JADRNÁ, L.; ZUMBERG, I.; LISICKÝ, O.; JAGOŠ, J.; ČMIEL, V.; BURŠA, J.

Original Title

MECHANICAL RESPONSE OF ENDOTHELIAL CELLS TO SHEAR FLOW AS POSSIBLE MARKER IN DEVELOPMENT OF ATHEROSCLEROSIS

English Title

MECHANICAL RESPONSE OF ENDOTHELIAL CELLS TO SHEAR FLOW AS POSSIBLE MARKER IN DEVELOPMENT OF ATHEROSCLEROSIS

Type

Paper in proceedings outside WoS and Scopus

Original Abstract

Arterial endothelium lies right at the interface between blood flow and the aortic wall and its disruption has been hypothesized as one of the crucial players in atherosclerosis development and progression. To address the physiological conditions of arterial endothelium we conducted a study of endothelial cell behaviour under shear stress. By interconnecting tailored experiments of cells under shear flow with computational modelling, we gained further insights into the behaviour of individual cells under shear stress. The main aim of the study was to evaluate the viability and extend the capabilities of previously-developed FEM structural models of cells [1,2]. We hypothesize that excessive deformation may lead up to a disruption of the cell attachment to the underlying substrate and thus play a major role in lipid penetration through the endothelium.

English abstract

Arterial endothelium lies right at the interface between blood flow and the aortic wall and its disruption has been hypothesized as one of the crucial players in atherosclerosis development and progression. To address the physiological conditions of arterial endothelium we conducted a study of endothelial cell behaviour under shear stress. By interconnecting tailored experiments of cells under shear flow with computational modelling, we gained further insights into the behaviour of individual cells under shear stress. The main aim of the study was to evaluate the viability and extend the capabilities of previously-developed FEM structural models of cells [1,2]. We hypothesize that excessive deformation may lead up to a disruption of the cell attachment to the underlying substrate and thus play a major role in lipid penetration through the endothelium.

Keywords

Endothelial cells; atherosclerosis; shear flow

Key words in English

Endothelial cells; atherosclerosis; shear flow

Authors

JADRNÁ, L.; ZUMBERG, I.; LISICKÝ, O.; JAGOŠ, J.; ČMIEL, V.; BURŠA, J.

Released

09.07.2023

Publisher

ESB

Location

Maastricht

Book

ESB 2023 BOOK OF ABSTRACTS

Pages count

1

URL

https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf

BibTex

@inproceedings{BUT184913,
  author="Lucie {Jadrná} and Inna {Zumberg} and Ondřej {Lisický} and Jiří {Jagoš} and Vratislav {Čmiel} and Jiří {Burša}",
  title="MECHANICAL RESPONSE OF ENDOTHELIAL CELLS TO SHEAR FLOW AS POSSIBLE MARKER IN DEVELOPMENT OF ATHEROSCLEROSIS",
  booktitle="ESB 2023 BOOK OF ABSTRACTS",
  year="2023",
  number="28",
  pages="1",
  publisher="ESB",
  address="Maastricht",
  url="https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf"
}