Prediction of Bone Marrow Biopsy Results From MRI in Multiple Myeloma Patients Using Deep Learning and Radiomics

Prediction of Bone Marrow Biopsy Results From MRI in Multiple Myeloma Patients Using Deep Learning and Radiomics

WoS Article

ObjectivesIn multiple myeloma and its precursor stages, plasma cell infiltration (PCI) and cytogenetic aberrations are important for staging, risk stratification, and response assessment. However, invasive bone marrow (BM) biopsies cannot be performed frequently and multifocally to assess the spatially heterogenous tumor tissue. Therefore, the goal of this study was to establish an automated framework to predict local BM biopsy results from magnetic resonance imaging (MRI).Materials and MethodsThis retrospective multicentric study used data from center 1 for algorithm training and internal testing, and data from center 2 to 8 for external testing. An nnU-Net was trained for automated segmentation of pelvic BM from T1-weighted whole-body MRI. Radiomics features were extracted from these segmentations, and random forest models were trained to predict PCI and the presence or absence of cytogenetic aberrations. Pearson correlation coefficient and the area under the receiver operating characteristic were used to evaluate the prediction performance for PCI and cytogenetic aberrations, respectively.ResultsA total of 672 MRIs from 512 patients (median age, 61 years; interquartile range, 53-67 years; 307 men) from 8 centers and 370 corresponding BM biopsies were included. The predicted PCI from the best model was significantly correlated (P & LE; 0.01) to the actual PCI from biopsy in all internal and external test sets (internal test set: r = 0.71 [0.51, 0.83]; center 2, high-quality test set: r = 0.45 [0.12, 0.69]; center 2, other test set: r = 0.30 [0.07, 0.49]; multicenter test set: r = 0.57 [0.30, 0.76]). The areas under the receiver operating characteristic of the prediction models for the different cytogenetic aberrations ranged from 0.57 to 0.76 for the internal test set, but no model generalized well to all 3 external test sets.ConclusionsThe automated image analysis framework established in this study allows for noninvasive prediction of a surrogate parameter for PCI, which is significantly correlated to the actual PCI from BM biopsy.

ObjectivesIn multiple myeloma and its precursor stages, plasma cell infiltration (PCI) and cytogenetic aberrations are important for staging, risk stratification, and response assessment. However, invasive bone marrow (BM) biopsies cannot be performed frequently and multifocally to assess the spatially heterogenous tumor tissue. Therefore, the goal of this study was to establish an automated framework to predict local BM biopsy results from magnetic resonance imaging (MRI).Materials and MethodsThis retrospective multicentric study used data from center 1 for algorithm training and internal testing, and data from center 2 to 8 for external testing. An nnU-Net was trained for automated segmentation of pelvic BM from T1-weighted whole-body MRI. Radiomics features were extracted from these segmentations, and random forest models were trained to predict PCI and the presence or absence of cytogenetic aberrations. Pearson correlation coefficient and the area under the receiver operating characteristic were used to evaluate the prediction performance for PCI and cytogenetic aberrations, respectively.ResultsA total of 672 MRIs from 512 patients (median age, 61 years; interquartile range, 53-67 years; 307 men) from 8 centers and 370 corresponding BM biopsies were included. The predicted PCI from the best model was significantly correlated (P & LE; 0.01) to the actual PCI from biopsy in all internal and external test sets (internal test set: r = 0.71 [0.51, 0.83]; center 2, high-quality test set: r = 0.45 [0.12, 0.69]; center 2, other test set: r = 0.30 [0.07, 0.49]; multicenter test set: r = 0.57 [0.30, 0.76]). The areas under the receiver operating characteristic of the prediction models for the different cytogenetic aberrations ranged from 0.57 to 0.76 for the internal test set, but no model generalized well to all 3 external test sets.ConclusionsThe automated image analysis framework established in this study allows for noninvasive prediction of a surrogate parameter for PCI, which is significantly correlated to the actual PCI from BM biopsy.

deep learning; segmentation; radiomics; MRI; bone marrow; biopsy; plasma cell infiltration; cytogenetic aberrations; multiple myeloma; multicenter

deep learning; segmentation; radiomics; MRI; bone marrow; biopsy; plasma cell infiltration; cytogenetic aberrations; multiple myeloma; multicenter

WENNMANN, M.; MING, W.; BAUER, F.; CHMELIK, J.; KLEIN, A.; UHLENBROCK, C.; GROZINGER, M.; KIM-CELINE, K.; NONNENMACHER, T.; DEBIC, M.; HIELSCHER, T.; THIERJUNG, H.; ROTKOPF, L.; STANZCYK, N.; SAUER, S.; JAUCH, A.; GOTZ, M.; KURZ, F.; SCHLAMP, K.; HORGER, M.; AFAT, S.; BESEMER, B.; HOFFMANN, M.; HOFFEND, J.; KRAEMER, D.; GRAEVEN, U.; RINGELSTEIN, A.; BONEKAMP, D.; KLEESIEK, J.; FLOCA, R.; HILLENGASS, J.; MAI, E.; WEINHOLD, N.; WEBER, T.; GOLDSCHMIDT, H.; SCHLEMMER, H.; MAIER-HEIN, K.; DELORME, S.; NEHER, P.

2024

08.09.2023

Wolters Kluwer Health, Inc.

0020-9996

INVESTIGATIVE RADIOLOGY

58

10

United States of America

754

765

12

https://journals.lww.com/investigativeradiology/fulltext/2023/10000/prediction_of_bone_marrow_biopsy_results_from_mri.7.aspx

http://hdl.handle.net/

Prediction_of_Bone_Marrow_Biopsy_Results_From_MRI.120