Publication result detail

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

SIEMASZKO, J.; MARZEC-PRZYSZLAK, A.; BOGUNIA-KUBIK, K.

Original Title

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

English Title

Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications

Type

WoS Article

Original Abstract

The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells. One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies. It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this receptor in immunosurveillance, especially in the human cytomegalovirus infection. Additionally, the authors attempt to shed some light on receptor’s unique interaction with its ligand which is shared with another receptor (CD94/NKG2A) with rather opposite properties.

English abstract

The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells. One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies. It outlines functional characteristics and molecular features of CD94/NKG2C, its interactions with HLA-E molecule and presented antigens, pointing out a key role of this receptor in immunosurveillance, especially in the human cytomegalovirus infection. Additionally, the authors attempt to shed some light on receptor’s unique interaction with its ligand which is shared with another receptor (CD94/NKG2A) with rather opposite properties.

Keywords

NK cell receptors;immunotherapy;ligand

Key words in English

NK cell receptors;immunotherapy;ligand

Authors

SIEMASZKO, J.; MARZEC-PRZYSZLAK, A.; BOGUNIA-KUBIK, K.

RIV year

2024

Released

10.03.2023

Publisher

Springer Nature

Location

Switzerland

ISBN

0004-069X

Periodical

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Volume

71

Number

1

State

Republic of Poland

Pages from

1

Pages to

18

Pages count

18

URL

https://link.springer.com/article/10.1007/s00005-023-00674-z

Full text in the Digital Library

http://hdl.handle.net/11012/213623

BibTex

@article{BUT183147,
  author="Jagoda {Siemaszko} and Aleksandra {Marzec-Przyszlak} and Katarzyna {Bogunia-Kubik}",
  title="Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications",
  journal="ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS",
  year="2023",
  volume="71",
  number="1",
  pages="1--18",
  doi="10.1007/s00005-023-00674-z",
  issn="0004-069X",
  url="https://link.springer.com/article/10.1007/s00005-023-00674-z"
}

Documents

s00005-023-00674-z