Publication detail

Encapsulation of bioactive proteins into thermosensitive biodegradable copolymer nanoparticles based on PLGA-PEG-PLGA

LYSÁKOVÁ, K. OBRŠLÍKOVÁ, M. KADLECOVÁ, Z. VOJTOVÁ, L.

Original Title

Encapsulation of bioactive proteins into thermosensitive biodegradable copolymer nanoparticles based on PLGA-PEG-PLGA

Type

abstract

Language

English

Original Abstract

The use of pro-healing proteins in regenerative medicine has become very widespread recently. One of the problems that can occur with protein release is the incorporation of the protein into the structure of the scaffold, their slow or no release, and their eventual loss of activity. Encapsulation of bioactive substances could prevent all of these problems. The thermosensitive copolymer based on poly(lactic acid), poly(glycolic acid), and poly(ethylene glycol) (PLGA–PEG–PLGA) was used in this work, mainly for the possibility of controlled degradation and gel formation at the human body temperature. The PLGA-PEG-PLGA copolymer consists of two hydrophobic segments (PLGA) and one hydrophilic segment (PEG) placed in the middle. Because of the amphiphilic properties, the copolymer self-assembles and physically cross-links into flower-shaped micelles. A thermostable 9-point mutant of fibroblast growth factor 2 (FGF2-STAB®, Enantis L.t.d.) was chosen as the bioactive component due to its ability to support the growth and the formation of new vessels.

Keywords

Thermosensitive copolymer, encapsulation, protein release

Authors

LYSÁKOVÁ, K.; OBRŠLÍKOVÁ, M.; KADLECOVÁ, Z.; VOJTOVÁ, L.

Released

29. 8. 2022

Publisher

Materials Research Society of Serbia

Location

Belgrade

ISBN

978-86-919111-7-1

Book

Program and Book of Abstracts TWENTY-THIRD ANNUAL CONFERENCE YUCOMAT 2022 & TWELFTH WORLD ROUND TABLE CONFERENCE ON SINTERING XII WRTCS

Pages from

157

Pages to

157

Pages count

184

URL

https://www.mrs-serbia.org.rs/index.php/book-of-abstracts-2022

BibTex

@misc{BUT179007,
  author="Klára {Lysáková} and Monika {Obršlíková} and Zuzana {Kadlecová} and Lucy {Vojtová}",
  title="Encapsulation of bioactive proteins into thermosensitive biodegradable copolymer nanoparticles based on PLGA-PEG-PLGA",
  booktitle="Program and Book of Abstracts
TWENTY-THIRD ANNUAL CONFERENCE YUCOMAT 2022 &
TWELFTH WORLD ROUND TABLE CONFERENCE ON SINTERING XII WRTCS",
  year="2022",
  pages="157--157",
  publisher="Materials Research Society of Serbia",
  address="Belgrade",
  isbn="978-86-919111-7-1",
  url="https://www.mrs-serbia.org.rs/index.php/book-of-abstracts-2022",
  note="abstract"
}