Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice

Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice

WoS Article

COOH plasma polymer layers deposited onto polycaprolactone (PCL) nanofibers by plasma polymerization of CO2 and C2H4 in the Ar atmosphere were obtained and tested for diabetic wound healing. Simply by changing the deposition time, very different morphologies of coated PCL nanofibers were achieved. In vivo tests revealed that by applying modified nanofibers for 10 days, wound healing accelerated by 32.1%. Compared to a controlled wound characterized by an acute inflammatory process, wounds covered with nanofibers with platelet-rich plasma demonstrated complete healing with a high percentage of collagen fibers on Day 19.

COOH plasma polymer layers deposited onto polycaprolactone (PCL) nanofibers by plasma polymerization of CO2 and C2H4 in the Ar atmosphere were obtained and tested for diabetic wound healing. Simply by changing the deposition time, very different morphologies of coated PCL nanofibers were achieved. In vivo tests revealed that by applying modified nanofibers for 10 days, wound healing accelerated by 32.1%. Compared to a controlled wound characterized by an acute inflammatory process, wounds covered with nanofibers with platelet-rich plasma demonstrated complete healing with a high percentage of collagen fibers on Day 19.

in vivo; polycaprolactone; type 2 diabetes mellitus; wound healing; XPS

in vivo; polycaprolactone; type 2 diabetes mellitus; wound healing; XPS

Solovieva, AO.; Permyakova, ES.; Ershov, KI.; Bakhareva, KI.; Miroshnichenko, SM.; Kiryukhantsev-Korneev, PV.; Konopatsky, AS.; Polcak, J.; Shtansky, DV.; Manakhov, AM

2023

01.07.2022

1612-8869

Plasma Processes and Polymers

19

7

Federal Republic of Germany

e2200032

12

https://onlinelibrary.wiley.com/doi/10.1002/ppap.202200032