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KADLECOVÁ, Z.; VOJTOVÁ, L.
Original Title
Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds
English Title
Type
Abstract
Original Abstract
This work aims to prepare an injectable thermosensitive drug delivery system enriched by biologically active substances to enhance healing. The mucoadhesive matrix was formed by an FDA-approved biocompatible, non-toxic synthetic polymer based on poly(lactide-co-glycolide) and poly(ethylene glycol) (PLGA-PEG-PLGA) copolymer functionalized with itaconic anhydride (ITA) patented by BUT. This polymer system is body thermo-responsive and is suggested for delivering a pro-healing protein – stable fibroblast growth factor-2 (FGF2-STAB® from Enantis L.t.d.), which stimulates re-epithelization and thus promotes overall tissue regeneration.
English abstract
Keywords
fibroblast growth factor-2; liposome; encapsulation
Key words in English
Authors
RIV year
2022
Released
20.04.2022
Publisher
Czech Chemical Society
ISBN
2336-7210
Periodical
Czech Chemical Society Symposium Series
Volume
20
Number
1
State
Czech Republic
Pages from
19
Pages to
Pages count
52
URL
http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
BibTex
@misc{BUT177961, author="Zuzana {Kadlecová} and Lucy {Vojtová}", title="Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds", year="2022", journal="Czech Chemical Society Symposium Series", volume="20", number="1", pages="19--20", publisher="Czech Chemical Society", issn="2336-7210", url="http://www.ccsss.cz/index.php/ccsss/issue/view/31/45", note="Abstract" }