Publication detail

Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds

KADLECOVÁ, Z. VOJTOVÁ, L.

Original Title

Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds

Type

abstract

Language

English

Original Abstract

This work aims to prepare an injectable thermosensitive drug delivery system enriched by biologically active substances to enhance healing. The mucoadhesive matrix was formed by an FDA-approved biocompatible, non-toxic synthetic polymer based on poly(lactide-co-glycolide) and poly(ethylene glycol) (PLGA-PEG-PLGA) copolymer functionalized with itaconic anhydride (ITA) patented by BUT. This polymer system is body thermo-responsive and is suggested for delivering a pro-healing protein – stable fibroblast growth factor-2 (FGF2-STAB® from Enantis L.t.d.), which stimulates re-epithelization and thus promotes overall tissue regeneration.

Keywords

fibroblast growth factor-2; liposome; encapsulation

Authors

KADLECOVÁ, Z.; VOJTOVÁ, L.

Released

20. 4. 2022

Publisher

Czech Chemical Society

ISBN

2336-7210

Periodical

Czech Chemical Society Symposium Series

Year of study

20

Number

1

State

Czech Republic

Pages from

19

Pages to

20

Pages count

52

URL

http://www.ccsss.cz/index.php/ccsss/issue/view/31/45

BibTex

@misc{BUT177961,
  author="Zuzana {Kadlecová} and Lucy {Vojtová}",
  title="Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds",
  year="2022",
  journal="Czech Chemical Society Symposium Series",
  volume="20",
  number="1",
  pages="19--20",
  publisher="Czech Chemical Society",
  issn="2336-7210",
  url="http://www.ccsss.cz/index.php/ccsss/issue/view/31/45",
  note="abstract"
}