Publication detail

Mitochondria morphology and membrane potential under stress conditions

EZATI, M. ZUMBERG, I. ČMIEL, V.

Original Title

Mitochondria morphology and membrane potential under stress conditions

Type

conference paper

Language

English

Original Abstract

Mitochondria, organelles found in the cytoplasm of almost all eukaryotic cells, generate large quantities of energy in the form of adenosine triphosphate (ATP). In addition to producing energy, mitochondria store calcium for cell signaling activities and play an important role in maintenance of ionic balance. Mitochondria, however, are highly sensitive to any kind of stress in which they mainly response by disturbance of respiration, reactive oxygen species (ROS) production and release of cytochrome c into the cytoplasm. Osmotic stress, in particular, generates ROS that degrade lipids, proteins, and DNA. High levels of salt concentration can cause an imbalance in cellular ion homeostasis that results in ion toxicity and osmotic stress. This study aims to investigate possible effects of KCl and NaCl on Bone marrow-derived (MSCs) mitochondria membrane potential (MMP) and morphology. The results indicated that KCl and NaCl of salt concentration can cause an imbalance in cellular ion homeostasis that results in ion toxicity and osmotic stress. This study aims to investigate possible effects of KCl and NaCl on MSCs mitochondria membrane potential (MMP) and morphology. The results indicated that KCl and NaCl decreased the potential and changed the morphology of mitochondria membrane compared to cells growing in normal condition.

Keywords

Mitochondria membrane potential, Mitochondria morphology, Osmotic stress, Mitochondria fusion

Authors

EZATI, M.; ZUMBERG, I.; ČMIEL, V.

Released

26. 4. 2022

Publisher

Brno University of Technology, Faculty of Electrical Engineering and Communication

Location

Brno

ISBN

978-80-214-6029-4

Book

Proceedings I of the 28th Conference STUDENT EEICT 2022 General Papers

Edition number

1

Pages from

432

Pages to

436

Pages count

5

URL

https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2022_sbornik_1_v2.pdf

BibTex

@inproceedings{BUT177723,
  author="Masoumeh {Ezati} and Inna {Zumberg} and Vratislav {Čmiel}",
  title="Mitochondria morphology and membrane potential under stress conditions",
  booktitle="Proceedings I of the 28th Conference STUDENT EEICT 2022 General Papers",
  year="2022",
  number="1",
  pages="432--436",
  publisher="Brno University of Technology, Faculty of Electrical Engineering and Communication",
  address="Brno",
  isbn="978-80-214-6029-4",
  url="https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2022_sbornik_1_v2.pdf"
}