Publication detail

Signal Transducer and Activator of Transcription 3 Signaling in Tumor Immune Evasion

ZHANG, L. KUČA, K. YOU, L. ZHAO, Y. MUSÍLEK, K. NEPOVIMOVÁ, E. WU, Q. WU, W. ADAM, V.

Original Title

Signal Transducer and Activator of Transcription 3 Signaling in Tumor Immune Evasion

Type

journal article in Web of Science

Language

English

Original Abstract

The underlying mechanism of tumor immune evasion is a highly concerning subject for researchers. Increasing evidences reveal that the over-activated signal transducer and activator of transcription 3 (STAT3) is a crucial molecular hub in malignant tumors. STAT3 controls autophagy molecules that impair CTL-mediated tumor cell lysis, inhibiting natural killer cells and inducing apoptosis in T lymphocytes to create an immunosuppressive environment. STAT3 signaling regulates the expression of immune factors and recruits immunosuppressive cells to establish a tolerant tumor microenvironment (TME). STAT3 signaling regulates the expression of immune factors and recruits immunosuppressive cells to create an immunosuppressive environment. All this aid tumor cells in escaping from immune surveillance. In this review, we outlined the STAT3-mediated mechanisms involved in tumor immune evasion and their potential regulatory functions in the TME. We discussed the impact of STAT3 signaling on PD-L1, HIF-1α, exosome, lncRNA, and autophagy in the promotion of tumor immune evasion and highlighted the recent research on STAT3 signaling and tumor immune evasion that may assist in developing effective STAT3-targeted drugs for advancing immunotherapy.

Keywords

Immune evasion; lncRNA; STAT3; Tumor microenvironment

Authors

ZHANG, L.; KUČA, K.; YOU, L.; ZHAO, Y.; MUSÍLEK, K.; NEPOVIMOVÁ, E.; WU, Q.; WU, W.; ADAM, V.

Released

28. 2. 2022

Publisher

Elsevier

ISBN

0163-7258

Periodical

PHARMACOLOGY & THERAPEUTICS

Year of study

230

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

11

Pages count

11

URL

https://www.sciencedirect.com/science/article/pii/S0163725821001716

Full text in the Digital Library

http://hdl.handle.net/11012/208402

BibTex

@article{BUT177313,
  author="Luying {Zhang} and Kamil {Kuča} and Li {You} and Yingying {Zhao} and Kamil {Musílek} and Eugenie {Nepovimová} and Qinghua {Wu} and Wenda {Wu} and Vojtěch {Adam}",
  title="Signal Transducer and Activator of Transcription 3 Signaling in Tumor Immune Evasion",
  journal="PHARMACOLOGY & THERAPEUTICS",
  year="2022",
  volume="230",
  number="1",
  pages="1--11",
  doi="10.1016/j.pharmthera.2021.107969",
  issn="0163-7258",
  url="https://www.sciencedirect.com/science/article/pii/S0163725821001716"
}