Publication result detail

„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; BRTNÍKOVÁ, J.; VOJTOVÁ, L.

Original Title

„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

English Title

„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release

Type

Abstract

Original Abstract

There is a strong emphasis on controlled drug delivery systems at this time. In this work stable Fibroblast growth factor 2 (FGF2-stab), developed by the Enantis company (Brno, CZ), was used as a protein-based drug. FGF2-stab stimulates the growth and the development of new vessels (angiogenesis), leading to improved wound healing, tissue development and contributes to the pathogenesis of several diseases (cancer or atherosclerosis). Amphiphilic PLGA-PEG-PLGA triblock copolymer was used as the biodegradable water-soluble copolymer that undergoes to a gel at physiological temperature. Along with increasing temperature in an aqueous environment, the PLGA-PEG-PLGA copolymer forms micelles having the hydrophobic core (PLGA) and the hydrophilic shell surface (PEG). Nowadays, drug carriers based on PLGA-PEG-PLGA copolymers are already commercially available under the names ReGel® and OncoGel® loaded with insulin or paclitaxel, respectively.

English abstract

There is a strong emphasis on controlled drug delivery systems at this time. In this work stable Fibroblast growth factor 2 (FGF2-stab), developed by the Enantis company (Brno, CZ), was used as a protein-based drug. FGF2-stab stimulates the growth and the development of new vessels (angiogenesis), leading to improved wound healing, tissue development and contributes to the pathogenesis of several diseases (cancer or atherosclerosis). Amphiphilic PLGA-PEG-PLGA triblock copolymer was used as the biodegradable water-soluble copolymer that undergoes to a gel at physiological temperature. Along with increasing temperature in an aqueous environment, the PLGA-PEG-PLGA copolymer forms micelles having the hydrophobic core (PLGA) and the hydrophilic shell surface (PEG). Nowadays, drug carriers based on PLGA-PEG-PLGA copolymers are already commercially available under the names ReGel® and OncoGel® loaded with insulin or paclitaxel, respectively.

Keywords

regenerative medicine, tissue engineering, biodegradable hydrogel matrix, protein release

Key words in English

regenerative medicine, tissue engineering, biodegradable hydrogel matrix, protein release

Authors

LYSÁKOVÁ, K.; HLINÁKOVÁ, K.; BRTNÍKOVÁ, J.; VOJTOVÁ, L.

RIV year

2022

Released

14.06.2021

Publisher

eCM Meeting Abstracts

ISBN

2522-235X

Periodical

eCM Periodical

Volume

2021

Number

1

State

Swiss Confederation

Pages from

25

Pages to

25

Pages count

1

URL

https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html

Full text in the Digital Library

http://hdl.handle.net/

BibTex

@misc{BUT175063,
  author="Klára {Tušlová} and Kristýna {Hlináková} and Jana {Brtníková} and Lucy {Vojtová}",
  title="„Smart“ biodegradable hydrogel as carrier for pro-healing proteins applicable in regenerative medicine: synthesis, characterization and controlled release",
  year="2021",
  journal="eCM Periodical",
  volume="2021",
  number="1",
  pages="25--25",
  publisher="eCM Meeting Abstracts",
  issn="2522-235X",
  url="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html",
  note="Abstract"
}