Publication detail

Ensemble based Machine Learning approach for Prediction of Glioma and Multi-grade Classification

Joshi, C., J. Mishra, R. Gandhi, P. Pathak, V., K. Burget, R. Dutta M.K.

Original Title

Ensemble based Machine Learning approach for Prediction of Glioma and Multi-grade Classification

Type

journal article in Web of Science

Language

English

Original Abstract

Glioma is the most pernicious cancer of the nervous system, with histological grade influencing the survival of patients. Despite many studies on the multimodal treatment approach, survival time remains brief. In this study, a novel two-stage ensemble of an ensemble-type machine learning-based predictive framework for glioma detection and its histograde classification is proposed. In the proposed framework, five characteristics belonging to 135 subjects were considered: human telomerase reverse transcriptase (hTERT), chitinase-like protein (YKL-40), interleukin 6 (IL-6), tissue inhibitor of metalloproteinase-1 (TIMP-1) and neutrophil/lymphocyte ratio (NLR). These characteristics were examined using distinctive ensemble-based machine learning classifiers and combination strategies to develop a computer-aided diagnostic system for the non-invasive prediction of glioma cases and their grade. In the first stage, the analysis was conducted to classify glioma cases and control subjects. Machine learning approaches were applied in the second stage to classify the recognised glioma cases into three grades, from grade II, which has a good prognosis, to grade IV, which is also known as glioblastoma. All experiments were evaluated with a five-fold cross-validation method, and the classification results were analysed using different statistical parameters. The proposed approach obtained a high value of accuracy and other statistical parameters compared with other state-of-the-art machine learning classifiers. Therefore, the proposed framework can be utilised for designing other intervention strategies for the prediction of glioma cases and their grades.

Keywords

Biomarkers; Ensemble Learning; Glioma; Machine Learning; Data Analysis

Authors

Joshi, C., J.; Mishra, R.; Gandhi, P.; Pathak, V., K.; Burget, R.; Dutta M.K.

Released

10. 6. 2021

Publisher

Computers in Biology and Medicine

ISBN

0010-4825

Periodical

COMPUTERS IN BIOLOGY AND MEDICINE

Year of study

Aug. 2021

Number

8

State

United States of America

Pages from

1

Pages to

22

Pages count

25

URL

https://www.sciencedirect.com/science/article/pii/S0010482521006235

BibTex

@article{BUT172412,
  author="Joshi, C., J. and Mishra, R. and Gandhi, P. and Pathak, V., K. and Burget, R. and Dutta M.K.",
  title="Ensemble based Machine Learning approach for Prediction of Glioma and Multi-grade Classification",
  journal="COMPUTERS IN BIOLOGY AND MEDICINE",
  year="2021",
  volume="Aug. 2021",
  number="8",
  pages="1--22",
  doi="10.1016/j.compbiomed.2021.104829",
  issn="0010-4825",
  url="https://www.sciencedirect.com/science/article/pii/S0010482521006235"
}