Detail publikačního výsledku

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

KRTIČKA, M.; MICHLOVSKÁ, L.; NEKUDA, V.; POLÁČEK, P.; VALOVÁ, K.; ŽÍDEK, J.; KAISER, J.; ZIKMUND, T.; VOJTOVÁ, L.

Original Title

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

English Title

Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue

Type

WoS Article

Original Abstract

This study aimed to answer the question whether our newly developed injectable biodegradable “self-setting” polymer composite as a bone adhesive is a good “bone-glue” candidate to efficiently fix comminuted fractures of pig femoral bone used as an ex-vivo experimental model. Mechanical properties of the adhesive prepared from α-tricalcium phosphate (TCP) powder and thermosensitive copolymer were optimized by selecting the appropriate composition with adhesion enhancers based on dopamine and sodium iodinate. Setting time and injectability were controlled by rheology. Ex-vivo experiments of fixed pig bones were provided in terms of either the three-point bending test of bending wedge type fractured pig femurs (with LCP) or the axial compression test of 45° oblique fractured femurs (without LCP). Fractured bones glued with optimized adhesive before and after bending tests were imaged by X-ray microtomography (μCT).

English abstract

This study aimed to answer the question whether our newly developed injectable biodegradable “self-setting” polymer composite as a bone adhesive is a good “bone-glue” candidate to efficiently fix comminuted fractures of pig femoral bone used as an ex-vivo experimental model. Mechanical properties of the adhesive prepared from α-tricalcium phosphate (TCP) powder and thermosensitive copolymer were optimized by selecting the appropriate composition with adhesion enhancers based on dopamine and sodium iodinate. Setting time and injectability were controlled by rheology. Ex-vivo experiments of fixed pig bones were provided in terms of either the three-point bending test of bending wedge type fractured pig femurs (with LCP) or the axial compression test of 45° oblique fractured femurs (without LCP). Fractured bones glued with optimized adhesive before and after bending tests were imaged by X-ray microtomography (μCT).

Keywords

biomechanics, adhesive, biodegradable polymer, bone, ex-vivo, fracture, microtomography, rheology, tixotropy

Key words in English

biomechanics, adhesive, biodegradable polymer, bone, ex-vivo, fracture, microtomography, rheology, tixotropy

Authors

KRTIČKA, M.; MICHLOVSKÁ, L.; NEKUDA, V.; POLÁČEK, P.; VALOVÁ, K.; ŽÍDEK, J.; KAISER, J.; ZIKMUND, T.; VOJTOVÁ, L.

RIV year

2021

Released

01.03.2021

Publisher

Elsevier Ltd

Location

RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS

ISBN

1751-6161

Periodical

Journal of the Mechanical Behavior of Biomedical Materials

Number

115

State

Kingdom of the Netherlands

Pages from

1

Pages to

8

Pages count

8

URL

https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S1751616120307888

Full text in the Digital Library

http://hdl.handle.net/

BibTex

@article{BUT170217,
  author="Milan {Krtička} and Lenka {Michlovská} and Vladimír {Nekuda} and Petr {Poláček} and Kristýna {Hlináková} and Jan {Žídek} and Jozef {Kaiser} and Tomáš {Zikmund} and Lucy {Vojtová}",
  title="Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue",
  journal="Journal of the Mechanical Behavior of Biomedical Materials",
  year="2021",
  number="115",
  pages="1--8",
  doi="10.1016/j.jmbbm.2020.104249",
  issn="1751-6161",
  url="https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S1751616120307888"
}