Publication detail

Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

KLOBUŠIAKOVÁ, P. MEKYSKA, J. BRABENEC, L. GALÁŽ, Z. ZVONČÁK, V. MUCHA, J. RAPCSAK, S. REKTOROVÁ, I.

Original Title

Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

Type

journal article in Web of Science

Language

English

Original Abstract

Introduction: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.

Keywords

acoustic analysis; hypokinetic dysarthria; fMRI; Parkinson's disease; voxel-based morphometry; resting-state functional connectivity

Authors

KLOBUŠIAKOVÁ, P.; MEKYSKA, J.; BRABENEC, L.; GALÁŽ, Z.; ZVONČÁK, V.; MUCHA, J.; RAPCSAK, S.; REKTOROVÁ, I.

Released

1. 3. 2021

Publisher

Elsevier

ISBN

1353-8020

Periodical

PARKINSONISM & RELATED DISORDERS

Year of study

84

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

122

Pages to

128

Pages count

7

URL

https://www.sciencedirect.com/science/article/pii/S1353802021000535

Full text in the Digital Library

http://hdl.handle.net/11012/203211

BibTex

@article{BUT169834,
  author="Patrícia {Klobušiaková} and Jiří {Mekyska} and Luboš {Brabenec} and Zoltán {Galáž} and Vojtěch {Zvončák} and Ján {Mucha} and Steven Z. {Rapcsak} and Irena {Rektorová}",
  title="Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures",
  journal="PARKINSONISM & RELATED DISORDERS",
  year="2021",
  volume="84",
  number="1",
  pages="122--128",
  doi="10.1016/j.parkreldis.2021.02.012",
  issn="1353-8020",
  url="https://www.sciencedirect.com/science/article/pii/S1353802021000535"
}