Publication result detail

In vitro bioactivity of silicon nitride-hydroxyapatite composites

Precnerova, M; Bodigova, K; Frajkorova, F; Galuskova, D; Novakova, ZV; Vojtassak, J; Lences, Z; Sajgalik, P

Original Title

In vitro bioactivity of silicon nitride-hydroxyapatite composites

English Title

In vitro bioactivity of silicon nitride-hydroxyapatite composites

Type

WoS Article

Original Abstract

Silicon nitride-based ceramics are characterised especially by high chemical resistance, superior combination of fracture toughness, hardness and bioinertness. However, the biological applications often require additional properties, e.g. bioactivity enabling stronger bonding to the host tissue. Hydroxyapatite coating prepared by sol gel route, which provides pure, stable and nano-crystalline product is one of the ways to achieve bioactivity of bioinert ceramics. Therefore silicon nitride hydroxyapatite composites were prepared by infiltration of hydroxyapatite precursor sol into the silicon nitride based porous ceramics. The conditions of sol preparation were optimised to be appropriate for pure HA synthesis: ageing at elevated temperature (85 degrees C) and calcinations at 500 degrees C for 1 h. Cytotoxicity and in vitro bioactivity of Si3N4-HA composites were tested in order to verify the effect of hydroxyapatite addition on the biological properties of composite. After immersion of porous composite into simulated body fluid (SBF) for 21 days, calcium phosphate layer was formed on the surface of silicon nitride hydroxyapatite composites, indicating their bioactivity. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

English abstract

Silicon nitride-based ceramics are characterised especially by high chemical resistance, superior combination of fracture toughness, hardness and bioinertness. However, the biological applications often require additional properties, e.g. bioactivity enabling stronger bonding to the host tissue. Hydroxyapatite coating prepared by sol gel route, which provides pure, stable and nano-crystalline product is one of the ways to achieve bioactivity of bioinert ceramics. Therefore silicon nitride hydroxyapatite composites were prepared by infiltration of hydroxyapatite precursor sol into the silicon nitride based porous ceramics. The conditions of sol preparation were optimised to be appropriate for pure HA synthesis: ageing at elevated temperature (85 degrees C) and calcinations at 500 degrees C for 1 h. Cytotoxicity and in vitro bioactivity of Si3N4-HA composites were tested in order to verify the effect of hydroxyapatite addition on the biological properties of composite. After immersion of porous composite into simulated body fluid (SBF) for 21 days, calcium phosphate layer was formed on the surface of silicon nitride hydroxyapatite composites, indicating their bioactivity. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Keywords

Si3N4; Apatite; Biomedical applications; Bioactivity

Key words in English

Si3N4; Apatite; Biomedical applications; Bioactivity

Authors

Precnerova, M; Bodigova, K; Frajkorova, F; Galuskova, D; Novakova, ZV; Vojtassak, J; Lences, Z; Sajgalik, P

RIV year

2020

Released

01.07.2015

Publisher

ELSEVIER SCI LTD

Location

OXFORD

ISBN

1873-3956

Periodical

Ceramics International

Volume

41

Number

6

State

United Kingdom of Great Britain and Northern Ireland

Pages from

8100

Pages to

8108

Pages count

9

URL

http://apps.webofknowledge.com.ezproxy.lib.vutbr.cz/full_record.do?product=WOS&search_mode=GeneralSearch&qid=22&SID=E6JXvEJHJpsw8EibggE&page=1&doc=1

BibTex

@article{BUT163563,
  author="Precnerova, M and Bodigova, K and Frajkorova, F and Galuskova, D and Novakova, ZV and Vojtassak, J and Lences, Z and Sajgalik, P",
  title="In vitro bioactivity of silicon nitride-hydroxyapatite composites",
  journal="Ceramics International",
  year="2015",
  volume="41",
  number="6",
  pages="8100--8108",
  doi="10.1016/j.ceramint.2015.03.011",
  issn="0272-8842",
  url="http://apps.webofknowledge.com.ezproxy.lib.vutbr.cz/full_record.do?product=WOS&search_mode=GeneralSearch&qid=22&SID=E6JXvEJHJpsw8EibggE&page=1&doc=1"
}