Publication result detail

Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells

ROSLI, N.; FOJTŮ, M.; FISHER, A.; PUMERA, M.

Original Title

Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells

English Title

Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells

Type

WoS Article

Original Abstract

Graphene oxide (GO) has been widely explored by many in drug delivery strategies and toxicity assays. The toxicity of graphene oxide depends on the size of the sheets. Smaller sheets show lower toxicity, a quality which is essential for utilization in biomedical applications. However, despite vast research on GO, anticancer properties and drug carrier capabilities of graphene oxide nanoplatelets have yet to be fully explored. Herein, we have uniquely prepared graphene oxide nanoplatelets (GONPs) from well-defined stacked graphite nanofibers (SGNF) with a base of 50 x 50 nm(2) for toxicity and drug potentiation studies when coadministered with the chemotherapeutic drug cisplatin (CP) in human lung cancer cells, A549 cells. Results obtained from our studies have found that not only were GONPs able to act as drug carriers, but they can also significantly potentiate anticancer effect of CP in A549 cells.

English abstract

Graphene oxide (GO) has been widely explored by many in drug delivery strategies and toxicity assays. The toxicity of graphene oxide depends on the size of the sheets. Smaller sheets show lower toxicity, a quality which is essential for utilization in biomedical applications. However, despite vast research on GO, anticancer properties and drug carrier capabilities of graphene oxide nanoplatelets have yet to be fully explored. Herein, we have uniquely prepared graphene oxide nanoplatelets (GONPs) from well-defined stacked graphite nanofibers (SGNF) with a base of 50 x 50 nm(2) for toxicity and drug potentiation studies when coadministered with the chemotherapeutic drug cisplatin (CP) in human lung cancer cells, A549 cells. Results obtained from our studies have found that not only were GONPs able to act as drug carriers, but they can also significantly potentiate anticancer effect of CP in A549 cells.

Keywords

TARGETED DELIVERY; CYTOTOXICITY; TOXICITY; NANOCARRIER; LABELS

Key words in English

TARGETED DELIVERY; CYTOTOXICITY; TOXICITY; NANOCARRIER; LABELS

Authors

ROSLI, N.; FOJTŮ, M.; FISHER, A.; PUMERA, M.

RIV year

2020

Released

26.02.2019

ISBN

0743-7463

Periodical

Langmuir

Volume

35

Number

8

State

United States of America

Pages from

3176

Pages to

3182

Pages count

7

URL

https://pubs.acs.org/doi/10.1021/acs.langmuir.8b03086

BibTex

@article{BUT158445,
  author="Nur Farhanah {Rosli} and Michaela {Fojtů} and Adrian C. {Fisher} and Martin {Pumera}",
  title="Graphene Oxide Nanoplatelets Potentiate Anticancer Effect of Cisplatin in Human Lung Cancer Cells",
  journal="Langmuir",
  year="2019",
  volume="35",
  number="8",
  pages="3176--3182",
  doi="10.1021/acs.langmuir.8b03086",
  issn="0743-7463",
  url="https://pubs.acs.org/doi/10.1021/acs.langmuir.8b03086"
}