Publication result detail

Ultrasonic study of hyaluronan interactions with Septonex – a pharmaceutical cationic surfactant

KARGEROVÁ, A.; PEKAŘ, M.

Original Title

Ultrasonic study of hyaluronan interactions with Septonex – a pharmaceutical cationic surfactant

English Title

Ultrasonic study of hyaluronan interactions with Septonex – a pharmaceutical cationic surfactant

Type

WoS Article

Original Abstract

Interactions between hyaluronan and the cationic surfactant Septonex were studied using high resolution ultrasound spectroscopy. Four different interaction regions were identified in aqueous solution in a narrow interval of surfactant concentrations. In contrast, in 0.15 mol/L NaCl solution, essentially only two principal regions were observed. Hyaluronan-Septonex aggregates were generally less compressible than Septonex monomers or micelles and their formation in water was not appreciably affected by hyaluronan molecular weight. In the presence of NaCl, the effect of hyaluronan molecular weight was more profound, which can be ascribed to its conformational sensitivity to ionic strength combined with its role as a surfactant counterion. Hyaluronan-Septonex interactions were closer to interactions with CTAB than with TTAB. Differences in structure or Krafft temperature (solubility) between Septonex and CTAB were thus not significantly reflected in these interactions. The basic characteristics of Septonex surfactant were also determined.

English abstract

Interactions between hyaluronan and the cationic surfactant Septonex were studied using high resolution ultrasound spectroscopy. Four different interaction regions were identified in aqueous solution in a narrow interval of surfactant concentrations. In contrast, in 0.15 mol/L NaCl solution, essentially only two principal regions were observed. Hyaluronan-Septonex aggregates were generally less compressible than Septonex monomers or micelles and their formation in water was not appreciably affected by hyaluronan molecular weight. In the presence of NaCl, the effect of hyaluronan molecular weight was more profound, which can be ascribed to its conformational sensitivity to ionic strength combined with its role as a surfactant counterion. Hyaluronan-Septonex interactions were closer to interactions with CTAB than with TTAB. Differences in structure or Krafft temperature (solubility) between Septonex and CTAB were thus not significantly reflected in these interactions. The basic characteristics of Septonex surfactant were also determined.

Keywords

hyaluronan; Septonex; ultrasonic velocity; compressibility; surfactant

Key words in English

hyaluronan; Septonex; ultrasonic velocity; compressibility; surfactant

Authors

KARGEROVÁ, A.; PEKAŘ, M.

RIV year

2019

Released

01.01.2019

ISBN

0144-8617

Periodical

Carbohydrate Polymers

Volume

204

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

17

Pages to

23

Pages count

7

URL

https://doi.org/10.1016/j.carbpol.2018.09.077

BibTex

@article{BUT150480,
  author="Andrea {Hurčíková} and Miloslav {Pekař}",
  title="Ultrasonic study of hyaluronan interactions with Septonex – a pharmaceutical cationic surfactant",
  journal="Carbohydrate Polymers",
  year="2019",
  volume="204",
  number="1",
  pages="17--23",
  doi="10.1016/j.carbpol.2018.09.077",
  issn="0144-8617",
  url="https://doi.org/10.1016/j.carbpol.2018.09.077"
}