Publication result detail

Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells

LACKOVÁ, Z.; BUCHTELOVÁ, H.; BUCHTOVÁ, Ž.; ADAM, V.; ZÍTKA, O.

Original Title

Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells

English Title

Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells

Type

Paper in proceedings (conference paper)

Original Abstract

In this study, the effect of selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells (PNT1A, 22RV1 and PC3) was observed. Synthetic standards of 3,4-dihydroxybenzaldehyde and naringenin chalcone, identified previously by HPLC-MS in black pepper seeds extracts, and neochlorogenic acid and apigenin, identified in caraway seeds extracts, were applied. For the evaluation of the potential inhibitory effect of selected compounds on PNT1A, 22RV1 and PC3 cells, the clonogenic assay and the microscopic observation of cells were done. The results of clonogenic assay showed that phenolic compounds had the strongest inhibitory effect on 22RV1 and PC3 cells, while the flavonoid compounds had the strongest inhibitory effect on PNT1A cells.

English abstract

In this study, the effect of selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells (PNT1A, 22RV1 and PC3) was observed. Synthetic standards of 3,4-dihydroxybenzaldehyde and naringenin chalcone, identified previously by HPLC-MS in black pepper seeds extracts, and neochlorogenic acid and apigenin, identified in caraway seeds extracts, were applied. For the evaluation of the potential inhibitory effect of selected compounds on PNT1A, 22RV1 and PC3 cells, the clonogenic assay and the microscopic observation of cells were done. The results of clonogenic assay showed that phenolic compounds had the strongest inhibitory effect on 22RV1 and PC3 cells, while the flavonoid compounds had the strongest inhibitory effect on PNT1A cells.

Keywords

Spices; clonogenic assay; phenolic compounds; flavonoid compounds; prostate cell lines

Key words in English

Spices; clonogenic assay; phenolic compounds; flavonoid compounds; prostate cell lines

Authors

LACKOVÁ, Z.; BUCHTELOVÁ, H.; BUCHTOVÁ, Ž.; ADAM, V.; ZÍTKA, O.

RIV year

2019

Released

31.12.2017

Publisher

Mendel University in Brno

ISBN

978-80-7509-529-9

Book

MendelNet 2017

Pages from

900

Pages to

904

Pages count

5

URL

https://mendelnet.cz/artkey/mnt-201701-0103_Effect-of-the-selected-phenolic-and-flavonoid-compounds-of-black-pepper-and-caraway-seeds-on-prostate-cells.php?back=/magno/mnt/2017/mn1.php?secid=4

Full text in the Digital Library

http://hdl.handle.net/11012/84188

BibTex

@inproceedings{BUT148746,
  author="Zuzana {Lacková} and Hana {Michálková} and Žaneta {Buchtová} and Vojtěch {Adam} and Ondřej {Zítka}",
  title="Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells",
  booktitle="MendelNet 2017",
  year="2017",
  pages="900--904",
  publisher="Mendel University in Brno",
  isbn="978-80-7509-529-9",
  url="https://mendelnet.cz/artkey/mnt-201701-0103_Effect-of-the-selected-phenolic-and-flavonoid-compounds-of-black-pepper-and-caraway-seeds-on-prostate-cells.php?back=/magno/mnt/2017/mn1.php?secid=4"
}

Documents

Effect of the selected phenolic and flavonoid compounds of black pepper and caraway seeds on prostate cells
MendelNet_mnt-201701-0103