Publication result detail

Generation of humanized bone-marrow-like niche in immunodeficient mice

ČULEN, M.; KOSAŘOVÁ, Z.; SOKOL, F.; CHOVANCOVÁ, J.; DVOŘÁKOVÁ, D.; VOJTOVÁ, L.; RÁČIL, Z.

Original Title

Generation of humanized bone-marrow-like niche in immunodeficient mice

English Title

Generation of humanized bone-marrow-like niche in immunodeficient mice

Type

Conference proceedings

Original Abstract

Imunodeficient mice represent a standard in vivo model for study of different types of human leukemias. Not all leukemic cells, however, do engraft/proliferate after xenotransplantation to mice, which is supposedly caused by inter-species differences. This problem can be resolved by introducing a humanized microenvironment into the animal recipients, via sub-cutaneous implantation of a suitable biomaterial and human mesenchymal stromal cells (MSC).

English abstract

Imunodeficient mice represent a standard in vivo model for study of different types of human leukemias. Not all leukemic cells, however, do engraft/proliferate after xenotransplantation to mice, which is supposedly caused by inter-species differences. This problem can be resolved by introducing a humanized microenvironment into the animal recipients, via sub-cutaneous implantation of a suitable biomaterial and human mesenchymal stromal cells (MSC).

Keywords

bone-marrow, immunodeficient mice, collagen scaffold, mesenchymal stomal cells

Key words in English

bone-marrow, immunodeficient mice, collagen scaffold, mesenchymal stomal cells

Authors

ČULEN, M.; KOSAŘOVÁ, Z.; SOKOL, F.; CHOVANCOVÁ, J.; DVOŘÁKOVÁ, D.; VOJTOVÁ, L.; RÁČIL, Z.

RIV year

2018

Released

20.04.2017

Publisher

Symma s.r.o.

Location

Brno

Pages from

41

Pages to

41

Pages count

62

BibTex

@proceedings{BUT145082,
  editor="Martin {Čulen} and Zdeňka {Kosařová} and Filip {Sokol} and Jana {Chovancová} and Dana {Dvořáková} and Lucy {Vojtová} and Zdeněk {Ráčil}",
  title="Generation of humanized bone-marrow-like niche in immunodeficient mice",
  year="2017",
  pages="41--41",
  publisher="Symma s.r.o.",
  address="Brno"
}