Detail publikačního výsledku

The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

JANOUŠEK, O.; STRAČINA, T.; RONZHINA, M.; HEJČ, J.; STARK, T.; RUDA, J.; MICALE, V.; KOLÁŘOVÁ, J.; NOVÁKOVÁ, M.; PROVAZNÍK, I.

Original Title

The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

English Title

The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats

Type

Paper in proceedings (conference paper)

Original Abstract

Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial values.

English abstract

Deeper understanding of heart rate variability (HRV) changes induced by haloperidol administration can contribute to overcoming of adverse cardiovascular effects of antipsychotics. The effect of haloperidol administration on HRV was therefore studied in nine schizophrenia-like rat isolated hearts and six control rat hearts. Isolated hearts were stabilized (20 min) on Langendorff perfusion system, then exposed to haloperidol (40 min) and finally washed out (40 min). The effect of haloperidol administration was studied in tachograms obtained from touchless-recorded electrograms (5 kHz, 12-bit). HRV parameters evolution in time, frequency, geometric, and non-linear domain were computed from 10 minutes long tachogram segments during stabilization, haloperidol exposition and washout periods. The haloperidol administration significantly affected HRV parameters in control rat hearts, but it had limited effect on schizophrenia-like ones. The effect of haloperidol administration was irreversible, since the washout did not restore HRV parameters to their initial values.

Keywords

Heart Rate Variability; Haloperidol

Key words in English

Heart Rate Variability; Haloperidol

Authors

JANOUŠEK, O.; STRAČINA, T.; RONZHINA, M.; HEJČ, J.; STARK, T.; RUDA, J.; MICALE, V.; KOLÁŘOVÁ, J.; NOVÁKOVÁ, M.; PROVAZNÍK, I.

RIV year

2018

Released

30.09.2017

Publisher

Computing in Cardiology 2017

Location

Rennes, France

ISBN

978-1-5090-0684-7

Book

Computing in Cardiology, 2017

Edition

44

ISBN

0276-6574

Periodical

Computers in Cardiology

State

United States of America

Pages from

1

Pages to

4

Pages count

4

Full text in the Digital Library

http://hdl.handle.net/

BibTex

@inproceedings{BUT141020,
  author="Oto {Janoušek} and Tibor {Stračina} and Marina {Filipenská} and Jakub {Hejč} and Tibor {Stark} and Jana {Ruda} and Vincenzo {Micale} and Jana {Kolářová} and Marie {Nováková} and Valentýna {Provazník}",
  title="The Effect of Haloperidol Administration on Heart Rate Variability in Isolated Heart of Schizophrenia-like and Control Rats",
  booktitle="Computing in Cardiology, 2017",
  year="2017",
  series="44",
  journal="Computers in Cardiology",
  number="1",
  pages="1--4",
  publisher="Computing in Cardiology 2017",
  address="Rennes, France",
  doi="10.22489/CinC.2017.150-161",
  isbn="978-1-5090-0684-7",
  issn="0276-6574"
}