Publication detail

Study of the glass transition of co-amorphous drug by DMA

TÜRKEOVÁ, I. SOLNÝ, T. KLUČÁKOVÁ, M.

Original Title

Study of the glass transition of co-amorphous drug by DMA

English Title

Study of the glass transition of co-amorphous drug by DMA

Type

conference paper

Language

en

Original Abstract

Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.

English abstract

Nowadays in pharmaceutical research is problem that new chemical entities are poorly water soluble and therefore present a low dissolution rate. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis (DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the pure co-amorphous form. Glass transition state is growing with addition of PVP.

Keywords

co-amorphous system, dynamic mechanical analysis, solubility drugs

Released

06.06.2016

Publisher

MUNI press

Location

Masaryk University, Brno, Czech Republic

ISBN

978-80-210-8267-0

Book

XVI. Workshop of physical chemists and electrochemists Book of abstracts

Edition

1

Pages from

212

Pages to

214

Pages count

3

Documents

BibTex


@inproceedings{BUT129225,
  author="Irena {Solná} and Tomáš {Solný} and Martina {Klučáková}",
  title="Study of the glass transition of co-amorphous drug by DMA
",
  annote="Nowadays in pharmaceutical research is problem that new chemical entities are poorly
water soluble and therefore present a low dissolution rate. One approach to increase their
solubility is to convert the crystalline form of a drug into the amorphous form.
In this study, the co-amorphous IND-TRY mixtures were prepared by mechanical
activation – ball milling. It was given different amount of polyvinylpyrrolidon to the mixture
and was characterized. Solid - state properties were analyzed by dynamic mechanical analysis
(DMA). It was found that addition of polyvinylpyrrolidon improved stability compared to the
pure co-amorphous form. Glass transition state is growing with addition of PVP.",
  address="MUNI press",
  booktitle="XVI. Workshop of physical chemists and electrochemists Book of abstracts",
  chapter="129225",
  edition="1",
  howpublished="electronic, physical medium",
  institution="MUNI press",
  year="2016",
  month="june",
  pages="212--214",
  publisher="MUNI press",
  type="conference paper"
}