Publication detail

N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

Lukáš Franke, Stanislav Pepeliaev, Radka Hrudíková, Zbyněk Černý, Dzinais Smirnou, Vladimír Velebný

Original Title

N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

English Title

N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

Type

abstract

Language

en

Original Abstract

Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.

English abstract

Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.

Keywords

N-acetylglucoseamin, hyaluronic acid, precursor, supplementation

Released

03.07.2016

Publisher

New Biotechnology

Location

Krakow, Poland

ISBN

1871-6784

Periodical

New Biotechnology

Year of study

33

Number

S

State

NL

Pages from

151

Pages to

151

Pages count

1

URL

Documents

BibTex


@misc{BUT128961,
  author="Radka {Hrudíková}",
  title="N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus",
  annote="Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.",
  address="New Biotechnology",
  chapter="128961",
  doi="10.1016/j.nbt.2016.06.1248",
  howpublished="online",
  institution="New Biotechnology",
  number="S",
  year="2016",
  month="july",
  pages="151--151",
  publisher="New Biotechnology",
  type="abstract"
}