Publication result detail

THE INFLUENCE OF VERTEX POTENTIAL AND MULTIPLE SCAN VOLTAMMETRY ON THE FORMATION OF 8-OXOGUANINE

GURECKÝ, L.; PILAŘOVÁ, I.; TRNKOVÁ, L.

Original Title

THE INFLUENCE OF VERTEX POTENTIAL AND MULTIPLE SCAN VOLTAMMETRY ON THE FORMATION OF 8-OXOGUANINE

English Title

THE INFLUENCE OF VERTEX POTENTIAL AND MULTIPLE SCAN VOLTAMMETRY ON THE FORMATION OF 8-OXOGUANINE

Type

Paper in proceedings (conference paper)

Original Abstract

The electrochemical behavior of guanosine (Guo) and guanosine-5´-monophosphate (GMP) at pencil graphite electrode (PeGE) in the phosphate-acetic buffer is examined by cyclic voltammetry (CV). The oxidation peaks of both compounds appear at 1.1 V naturally, but using a multiple cycle we observed an additional peak. It was found that this peak corresponds to oxidation of 8-oxo-7,8-dihydroguanine (8-oG). To determine the potential of 8-oG formation we changed positive vertex potentials in the range from 0.9 to 1.4 V vs. Ag/AgCl/3MKCl reference electrode. The lowest vertex potential at which the 8-oG provided response corresponds to 1.3V for both Guo and GMP (pH 4.16). The most important is the fact that the appearance of the 8-oG peak always occurs after the first cycle of CV.

English abstract

The electrochemical behavior of guanosine (Guo) and guanosine-5´-monophosphate (GMP) at pencil graphite electrode (PeGE) in the phosphate-acetic buffer is examined by cyclic voltammetry (CV). The oxidation peaks of both compounds appear at 1.1 V naturally, but using a multiple cycle we observed an additional peak. It was found that this peak corresponds to oxidation of 8-oxo-7,8-dihydroguanine (8-oG). To determine the potential of 8-oG formation we changed positive vertex potentials in the range from 0.9 to 1.4 V vs. Ag/AgCl/3MKCl reference electrode. The lowest vertex potential at which the 8-oG provided response corresponds to 1.3V for both Guo and GMP (pH 4.16). The most important is the fact that the appearance of the 8-oG peak always occurs after the first cycle of CV.

Keywords

guanosine; guanosine - 5 - monophosphate; PeGE; cyclic voltammetry; EVP

Key words in English

guanosine; guanosine - 5 - monophosphate; PeGE; cyclic voltammetry; EVP

Authors

GURECKÝ, L.; PILAŘOVÁ, I.; TRNKOVÁ, L.

RIV year

2016

Released

21.03.2015

ISBN

978-80-210-7857-4

Book

XV. Workshop of Physical Chemists and Electrochemists

Pages from

87

Pages to

90

Pages count

4

BibTex

@inproceedings{BUT120384,
  author="Libor {Gurecký} and Iveta {Pilařová} and Libuše {Trnková}",
  title="THE INFLUENCE OF VERTEX POTENTIAL AND MULTIPLE SCAN VOLTAMMETRY ON THE FORMATION OF 8-OXOGUANINE",
  booktitle="XV. Workshop of Physical Chemists and Electrochemists",
  year="2015",
  number="1",
  pages="87--90",
  isbn="978-80-210-7857-4"
}