Publication detail

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

EL-SHAMY, I. ABDEL-LATTIF, A. FOUDA, M. AL-DEYAB, S. EL-HASHASH, M.

Original Title

Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine

Type

journal article in Web of Science

Language

English

Original Abstract

1-Chloro-4-(2,4,6-trimethylphenyl)phthalazine (2) was used as a precursor for preparation of some novel pyrazolylphthalazine derivatives 6-13 and 15-19. Moreover, the acyclonucleosides 20-23 a-e were prepared by the reaction of hydrazinophthalazine derivative 3 with different aldoses. All new phthalazine derivatives were characterized using 1H NMR, 13C NMR, FTIR, mass spectrum and elemental analysis. The newly synthesized compounds showed highly activity against different species of bacteria and fungi, in addition to an excellent antiinflammatory property.

Keywords

C-nucleosides, Phthalazine derivatives, Biological activity

Authors

EL-SHAMY, I.; ABDEL-LATTIF, A.; FOUDA, M.; AL-DEYAB, S.; EL-HASHASH, M.

RIV year

2014

Released

1. 7. 2014

ISBN

0970-7077

Periodical

ASIAN JOURNAL OF CHEMISTRY

Year of study

26

Number

14

State

Republic of India

Pages from

4405

Pages to

4415

Pages count

11

BibTex

@article{BUT112240,
  author="Ibrahim E. {El-Shamy} and Abdelmohsen Moustafa {Abdellatif} and Moustafa M.D. {Fouda} and Salem S. {Al-Deyab} and Maher A. {El-Hashash}",
  title="Synthesis of Some Biologically Active Pyrazolylphthalazine Derivatives and Acyclo-C-nucleosides of 6-(2,4,6-trimethylphenyl)-1,2,4-triazolo[3,4-a]phthalazine",
  journal="ASIAN JOURNAL OF CHEMISTRY",
  year="2014",
  volume="26",
  number="14",
  pages="4405--4415",
  issn="0970-7077"
}