Publication result detail

Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry

KENŠOVÁ, R.; HYNEK, D.; KYNICKÝ, J.; NOVOTNÁ, M.; ECKSCHLAGER, T.; ADAM, V.; HUBÁLEK, J.; KIZEK, R.

Original Title

Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry

English Title

Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry

Type

WoS Article

Original Abstract

The aim of this study was to investigate the interaction between lead ions and ethylenediaminetetraacetic acid (EDTA) in plasma. EDTA is widely used in medicine as anticoagulant agent. Understanding of the influence of EDTA on the electrochemical lead ions determination is very suitable for the determination of lead ions at patients with increased metals levels in body fluids. Further, the changes of metal ions levels (Zn, Cd, Pb and Cu) were monitored in the blood plasma of child patients treated for various oncological diseases. Electrochemical method differential pulse voltammetry with fully automated system and atomic absorption spectrometry was used for determination of the metal ions. It was found an increased amount of metal ions in the blood plasma of patients suffering from cancer disease in comparison with physiological values in healthy people. In these patients there was also found that they have higher levels of metallothionein and the ratio of GSH/GSSG was reduced. These results suggest that tumour diseases cause important changes in the level of ions.

English abstract

The aim of this study was to investigate the interaction between lead ions and ethylenediaminetetraacetic acid (EDTA) in plasma. EDTA is widely used in medicine as anticoagulant agent. Understanding of the influence of EDTA on the electrochemical lead ions determination is very suitable for the determination of lead ions at patients with increased metals levels in body fluids. Further, the changes of metal ions levels (Zn, Cd, Pb and Cu) were monitored in the blood plasma of child patients treated for various oncological diseases. Electrochemical method differential pulse voltammetry with fully automated system and atomic absorption spectrometry was used for determination of the metal ions. It was found an increased amount of metal ions in the blood plasma of patients suffering from cancer disease in comparison with physiological values in healthy people. In these patients there was also found that they have higher levels of metallothionein and the ratio of GSH/GSSG was reduced. These results suggest that tumour diseases cause important changes in the level of ions.

Keywords

Metals; Electrochemical Analysis; Plasma; EDTA; Interaction; Oncological Diseases

Key words in English

Metals; Electrochemical Analysis; Plasma; EDTA; Interaction; Oncological Diseases

Authors

KENŠOVÁ, R.; HYNEK, D.; KYNICKÝ, J.; NOVOTNÁ, M.; ECKSCHLAGER, T.; ADAM, V.; HUBÁLEK, J.; KIZEK, R.

Released

01.08.2014

Publisher

ESG

ISBN

1452-3981

Periodical

International Journal of Electrochemical Science

Volume

9

Number

8

State

Republic of Serbia

Pages from

4675

Pages to

4691

Pages count

17

URL

http://www.electrochemsci.org/papers/vol9/90804675.pdf

Full text in the Digital Library

http://hdl.handle.net/11012/201446

BibTex

@article{BUT111179,
  author="Renáta {Kenšová} and David {Hynek} and Jindřich {Kynický} and Marie {Novotná} and Tomáš {Eckschlager} and Vojtěch {Adam} and Jaromír {Hubálek} and René {Kizek}",
  title="Determination of Metal Ions in the Plasma of Children with Tumour Diseases by Differential Pulse Voltammetry",
  journal="International Journal of Electrochemical Science",
  year="2014",
  volume="9",
  number="8",
  pages="4675--4691",
  issn="1452-3981",
  url="http://www.electrochemsci.org/papers/vol9/90804675.pdf"
}

Documents

90804675