Publication result detail

Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods

KOMÍNKOVÁ, M.; GURÁŇ, R.; MERLOS RODRIGO, M.; KOPEL, P.; BLAŽKOVÁ, I.; CHUDOBOVÁ, D.; NEJDL, L.; HEGER, Z.; RUTTKAY-NEDECKÝ, B.; ZÍTKA, O.; ADAM, V.; KIZEK, R.

Original Title

Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods

English Title

Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods

Type

WoS Article

Original Abstract

This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times.

English abstract

This study points to changes in the properties of liposomes and its functional qualities in task of release of encapsulated drug doxorubicin according to the content of cholesterol in the phospholipid bilayer. The influence of sodium dodecyl sulphate (SDS) addition to liposomal variants was also evaluated too. Three variants of liposomes differing in various concentrations of cholesterol were assessed. Firstly, we focused on the toxicity of all liposomal variants to Staphyloccocus aureus and it was found that the content of cholesterol increases the IC50 values of encapsulated doxorubicin in liposome with higher concentration of cholesterol than in liposome without cholesterol even four times.

Keywords

Liposome; Cholesterol; Doxorubicin; Sodium Dodecyl Sulphate; Drug Delivery; Drug Encapsulation;

Key words in English

Liposome; Cholesterol; Doxorubicin; Sodium Dodecyl Sulphate; Drug Delivery; Drug Encapsulation;

Authors

KOMÍNKOVÁ, M.; GURÁŇ, R.; MERLOS RODRIGO, M.; KOPEL, P.; BLAŽKOVÁ, I.; CHUDOBOVÁ, D.; NEJDL, L.; HEGER, Z.; RUTTKAY-NEDECKÝ, B.; ZÍTKA, O.; ADAM, V.; KIZEK, R.

Released

23.03.2014

ISBN

1452-3981

Periodical

International Journal of Electrochemical Science

Volume

9

Number

6

State

Republic of Serbia

Pages from

2993

Pages to

3007

Pages count

15

BibTex

@article{BUT106912,
  author="Markéta {Komínková} and Roman {Guráň} and Miguel Ángel {Merlos Rodrigo} and Pavel {Kopel} and Iva {Blažková} and Dagmar {Hegerová} and Lukáš {Nejdl} and Zbyněk {Heger} and Branislav {Ruttkay-Nedecký} and Ondřej {Zítka} and Vojtěch {Adam} and René {Kizek}",
  title="Study of Functional Qualities of Different Types of Tailored Liposomes with Encapsulated Doxorubicin using Electrochemical and Optical Methods",
  journal="International Journal of Electrochemical Science",
  year="2014",
  volume="9",
  number="6",
  pages="2993--3007",
  issn="1452-3981"
}