Publication result detail

Metallothionein polymorphisms in pathological processes

RAUDENSKÁ, M.; GUMULEC, J.; PODLAHA, O.; SZTALMACHOVÁ, M.; BABULA, P.; ECKSCHLAGER, T.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

Original Title

Metallothionein polymorphisms in pathological processes

English Title

Metallothionein polymorphisms in pathological processes

Type

WoS Article

Original Abstract

Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications.This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies.

English abstract

Metallothioneins (MTs) are a class of metal-binding proteins characterized by a high cysteine content and low molecular weight. MTs play an important role in metal metabolism and protect cells against the toxic effects of radiation, alkylating agents and oxygen free radicals. The evidence that individual genetic characteristics of MTs play an important role in physiological and pathological processes associated with antioxidant defense and detoxification inspired targeted studies of genetic polymorphisms in a clinical context. In recent years, common MT polymorphisms were identified and associated with, particularly, western lifestyle diseases such as cancer, complications of atherosclerosis, and type 2 diabetes mellitus along with related complications.This review summarizes all evidence regarding MT polymorphisms of major human MTs (MT1, MT2, MT3 and MT4), their relation to pathological processes, and outlines specific applications of MTs as a set of genetic markers for certain pathologies.

Keywords

Metallothionein, pathological processes, protein

Key words in English

Metallothionein, pathological processes, protein

Authors

RAUDENSKÁ, M.; GUMULEC, J.; PODLAHA, O.; SZTALMACHOVÁ, M.; BABULA, P.; ECKSCHLAGER, T.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

Released

01.01.2014

ISBN

1756-5901

Periodical

Metallomics

Volume

6

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

55

Pages to

68

Pages count

14

BibTex

@article{BUT106911,
  author="Martina {Raudenská} and Jaromír {Gumulec} and Ondřej {Podlaha} and Markéta {Sztalmachová} and Petr {Babula} and Tomáš {Eckschlager} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="Metallothionein polymorphisms in pathological processes",
  journal="Metallomics",
  year="2014",
  volume="6",
  number="1",
  pages="55--68",
  doi="10.1039/c3mt00132f",
  issn="1756-5901"
}