Antibiotic-resistant biofilms pose major challenges. We will develop a non-antibiotic strategy using Janus magnetic-living hydrogel biobots integrating probiotic Bacillus subtilis and Fe3O4 nanoparticles via droplet microfluidics. Under rotating magnetic fields, the magnetic hemisphere will generate strong shear to disrupt biofilm matrix, whereas such actuation will not be achievable in homogeneously loaded structures, while the probiotic side will secrete antibacterial compounds for synergistic eradication.

CEITEC VUT-J-26-9060

Czech

Song Yanzhen, M.Sc. - principal person responsible
Pumera Martin, prof. RNDr., Ph.D. - fellow researcher

Central European Institute of Technology BUT
- responsible department (29.1.2026 - not assigned)
Future Energy and Innovation
- internal (1.1.2026 - 31.12.2026)
Central European Institute of Technology BUT
- beneficiary (1.1.2026 - 31.12.2026)

Responsibility: Song Yanzhen, M.Sc.