Metastasis is the main cause of cancer-related death, yet few therapies target tumor invasion. The concept of migrastatics proposes drugs that immobilize cancer cells by inhibiting protrusion and contractility. This project evaluates candidate drugs and their effects on cell motility and cytoskeletal dynamics using advanced imaging in 2D and 3D models. Expected result include new perspectives into invasive plasticity, identification of repurposed anti-invasive drugs, and strategies that complement conventional cancer therapies.

CEITEC VUT-J-26-9002

Czech

Shiotani Marcondes Michaela, M.Sc. - principal person responsible
Zicha Daniel, doc. Ing., CSc. - fellow researcher

Central European Institute of Technology BUT
- responsible department (26.1.2026 - not assigned)
Experimental Biophotonics
- internal (1.1.2026 - 31.12.2026)
Central European Institute of Technology BUT
- beneficiary (1.1.2026 - 31.12.2026)

Responsibility: Shiotani Marcondes Michaela, M.Sc.