Theranostics (therapy and diagnostics) represent a new basis for a modern approach to treatment. Stroke is a significant burden on the modern society nowadays (not only after the SARS-CoV-2 pandemic). This project aims to study the pharmacokinetic properties of polyiodinated biodegradable nanoparticles (IoNPs) based on theranostics using a novel combination of in vivo and ex vivo imaging methods. On this basis, it further aims to develop (using a future image database developed by us) the detection of ischemic stroke age on tissue sections in a combination of machine learning methods. The results of this project will have a significant impact on society as a whole, ranging from the possibility of applying IoNPs in clinical practice, to the necessary choice of individual patient treatment to save their life, to the reduced economic burden associated with long-term treatment, rehabilitation and loss of productivity.

Keywords
ischemic stroke;contrast agent;biodegradable nanoparticles;laser ablation;pharmacokinetics of nanoparticles;artifical inteligence;machine learning methods

25-16166S

English

Pořízka Pavel, doc. Ing., Ph.D. - principal person responsible
Vrábel Jakub, Ing., Ph.D. - fellow researcher

Advanced instrumentation and methods for material characterization
- responsible department (1.4.2024 - not assigned)
Advanced instrumentation and methods for material characterization
- beneficiary (1.4.2024 - not assigned)

Dumková, J.; Vaskovicová, N.; Kristeková, D.; Vrlíková, L.; Faruzelová, A.; Jedlicková, A.; Tatícková, M.; Alexa, L.; Coufalík, P.; Bahelková, M.; Cigánková, H.; Vecera, Z.; Lusková, D.; Jakesová, V.; Krumal, K.; Hegrová, J.; Porízka, P.; Kaiser, J.; Vaculovic, T.; Kanicky, V.; Mikuska, P.; Hampl, A.; Buchtová, M. Secondary target organs exhibit differential ability to clear cadmium after cadmium oxide nanoparticle inhalation. JOURNAL OF HAZARDOUS MATERIALS, 2025, vol. 496, no. 139181, 24 p. ISSN: 1873-3336.
Detail

Responsibility: Pořízka Pavel, doc. Ing., Ph.D.