A novel therapeutic option for patients with critical-sized skin wounds has emerged: 3D scaffolds. This project aims to prepare and evaluate a second generation collagen-based scaffold that mimics the dermis of the human skin grafted with hypoxia-inducible factors (HIFs). For the adequate vascularization process dimethyloxalylglycine (DMOG) as HIF will be added to the scaffold to support cell proliferation, angiogenesis and to prevent cell death after application.

Keywords
Wound dressing, scaffold, collagen, chitosan, dermis, regenerative medicine, drug release, vascularization

CEITEC VUT-J-24-8629

Czech

Izsák Dávid, Ing. - principal person responsible
Pavliňáková Veronika, Mgr., Ph.D. - fellow researcher

Advanced Biomaterials
- responsible department (4.3.2024 - not assigned)
Central European Institute of Technology BUT
- responsible department (30.1.2024 - 4.3.2024)
Advanced Biomaterials
- beneficiary (1.1.2024 - 31.12.2024)

IZSÁK, D.; PAVLIŇÁKOVÁ, V.; FOHLEROVÁ, Z.; SZOTKOWSKÁ, T.; BUCHTOVÁ, M.; VOJTOVÁ, L. Advanced 3D collagen-based scaffolds enriched with vasculogenic compound for enhanced vascularization and wound healing. 21st International Conference on Nanosciences & Nanotechnologies, Book of Abstract, Greece, Thessaloniki, 2-5 July 2024. Thessaloniki, Greece: 2024. p. 171-171.
Detail

IZSÁK, D.; PAVLIŇÁKOVÁ, V.; FOHLEROVÁ, Z.; SZOTKOWSKÁ, T.; BUCHTOVÁ, M.; VOJTOVÁ, L. Advanced 3D collagen-based scaffolds modified with pro-angiogenic molecule for wound healing. Bioimplantologie a regenerativní medicína 2024. Praha: 2024. p. 35-35. ISBN: 978-80-01-07293-6.
Detail

Responsibility: Izsák Dávid, Ing.