The project deals with theranostic nanoparticles based on liposomal siRNA-complex (lipoplex), which can handle requirements on a successful anticancer drug nanoformulation. Lipoplexes are made by injection method to form bilayer particles, and therapeutic siRNA is inserted into the lipoplex core by electrostatic interactions. Lipoplexes will combine unique gene silencing therapy properties with diagnostic capabilities mediated by gadolinium-based contrast agents. These multiunctional nanoparticles will pave new avenues for cancer theranostics.

CEITEC VUT-J-22-7814

Czech

Vojníková Michaela, Ing. - principal person responsible
Heger Zbyněk, doc. Mgr., Ph.D. - fellow researcher

Central European Institute of Technology BUT
- responsible department (13.1.2022 - 3.3.2022)
Smart Nanodevices
- responsible department (3.3.2022 - not assigned)
Smart Nanodevices
- co-beneficiary (1.3.2022 - 28.2.2023)
Central European Institute of Technology BUT
- beneficiary (1.1.2022 - 31.12.2022)

MARÁKOVÁ, E.; VOJNÍKOVÁ, M.; MILLER, A.; GRUBEROVÁ, E.; HEGER, Z. Advanced Lipid-Based Nanotransporters for Encapsulation of Cytochrome C. In Proceedings of the 9th World Congress on Recent Advances in Nanotechnology. London: INTERNATIONAL ASET INC. – ALL, 2024. 2 p. ISBN: 9781990800337.
Detail

Responsibility: Vojníková Michaela, Ing.