PAMMOTH's objective is to develop, validate and begin exploitation of a dedicated breast imaging device for a significant impact in breast cancer diagnosis. The proposed device combines non-invasive 3D photoacoustic imaging and laser-induced ultrasound imaging. The device will provide near real-time, full-breast, multimodal images to the radiologist. From the ultrasound mode, the radiologist will visualize anatomical features and extent of tumors, and from multiwavelength photoacoustics, she will see tumor vascularity. Quantitative spectroscopic photoacoustic images will be extracted off-line, providing the radiologist information relating to tumor physiology and function such as angiogenesis and hypoxia. The choice of the relevant biological targets, and of the functionalities and technical principles applied in the PAMMOTH imager, will enable sensitive, accurate and quantitative measurements of these targets. This will provide relevant information to the radiologist to make accurate diagnosis with high specificity. We aim to make the imaging device such for all populations of women, with short time intervals between positive screening and diagnosis, having high through-put, possessing no carcinogenic potential and causing no pain and discomfort to patients.

Description in Czech
Cílem projektu PAMMOTH je vyvinout, validovat a uvést do praxe nový přístroj pro neinvazivní screening prsou s cílem o včasnou diagnozu rakoviny prsou. Navržené zařízení kombinuje 3D fotoakustické snímkování a laserem indukované ultrazvukové snímkování. Cílem je dosáhnout vysoké přesnosti detekce v reálném čase.

Keywords
photoacoustic imaging, laser-induced ultrasound, high performance computing, numerical methods, breast cancer

PAMMOTH

English

Jaroš Jiří, prof. Ing., Ph.D. - principal person responsible

Department of Computer Systems
- responsible department (18.4.2016 - not assigned)
Department of Computer Systems
- responsible department (8.2.2021 - not assigned)
Supercomputing Technologies Research Group SC@FIT
- internal (18.4.2016 - 30.6.2021)
Department of Computer Systems
- co-beneficiary (18.4.2016 - 30.6.2021)
EKSPLA
- co-beneficiary (18.4.2016 - 30.6.2021)
Imasonic SAS
- co-beneficiary (18.4.2016 - 30.6.2021)
Medisch Spectrum Twente
- co-beneficiary (18.4.2016 - 30.6.2021)
PA Imaging Holding BV
- co-beneficiary (18.4.2016 - 30.6.2021)
tp21 GmbH
- co-beneficiary (18.4.2016 - 30.6.2021)
tp21 GmbH
- co-beneficiary (18.4.2016 - 30.6.2021)
University College London
- co-beneficiary (18.4.2016 - 30.6.2021)
University of Bern
- co-beneficiary (18.4.2016 - 30.6.2021)
University of Bern
- co-beneficiary (18.4.2016 - 30.6.2021)
University of Twente
- beneficiary (18.4.2016 - 30.6.2021)

JAROŠ, M.; JAROŠ, J. Performance-Cost Optimization of Moldable Scientific Workflows. In Job Scheduling Strategies for Parallel Processing. Lecture Notes in Computer Science. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Portland, Oregon USA: Springer International Publishing, 2021. p. 149-167. ISBN: 978-3-030-88223-5. ISSN: 0302-9743.
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KADLUBIAK, K.; JAROŠ, J.; TREEBY, B. GPU-accelerated Simulation of Elastic Wave Propagation. Frankfurt am Main: 2018. p. 0 (1 s.).
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VAVERKA, F.; ŠPEŤKO, M.; TREEBY, B.; JAROŠ, J. Optimization of Ultrasound Simulations on Multi-GPU Servers. Dallas: 2018. p. 1-2.
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JAROŠ, M.; TREEBY, B.; JAROŠ, J. Design of HIFU Treatment Plans using an Evolutionary Strategy. Ostrava: 2018. p. 1 (1 s.).
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KADLUBIAK, K.; TREEBY, B.; JAROŠ, J. Fourth-order Time-stepping Scheme in Simulation of Ultrasound Propagation. Ostrava: 2018. p. 1 (1 s.).
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VAVERKA, F.; TREEBY, B.; JAROŠ, J. Running Large-Scale Ultrasound Simulations on Intel Xeon Phi (KNC) accelerators. Ostrava: 2018. p. 1 (1 s.).
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BORDOVSKÝ, G.; COX, B.; JAROŠ, J. Photoacoustic Tomography Using the k-Wave Toolbox. Ostrava: 2018. p. 1 (1 s.).
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DANTUMA, M.; LUCKA, F.; TREEBY, B.; JAROŠ, J.; COX, B.; MANOHAR, S. Signal Frequency Content and Appearance of Tumors in Photoacoustic Breast Tomography: A Simulation. Caparica: 2018. p. 1 (1 s.).
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JAROŠ, M.; JAROŠ, J. Framework for Planning, Executing and Monitoring Cooperating Computations. Ostrava: 2017. p. 0-0.
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VAVERKA, F.; TREEBY, B.; JAROŠ, J. Running Large-Scale Ultrasound Simulations on 256 Salomon Nodes. Ostrava: 2017. p. 1 (1 s.).
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VAVERKA, F.; TREEBY, B.; JAROŠ, J. Running Large-Scale Ultrasound Simulations on Piz Daint with 512 Pascal GPUs. Denver: 2017. p. 1 (1 s.).
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JAROŠ, J. High Performance Computing in Ultrasound Cancer Treatment. Brno: 2017. p. 0-0.
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VAVERKA, F.; TREEBY, B.; JAROŠ, J. Performance Evaluation of Pseudospectral Ultrasound Simulations on a Cluster of Xeon Phi Accelerators. In High Performance Computing in Science and Engineering. HPCSE 2019. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Cham: Springer Nature Switzerland AG, 2021. p. 99-115. ISBN: 978-3-030-67076-4.
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PHAM, K.; NOIMARK, S.; HUYNH, N.; ZHANG, E.; KUKLIŠ, F.; JAROŠ, J.; DESJARDINS, A.; COX, B.; BEARD, P. Broadband all-optical plane-wave ultrasound imaging system based on a Fabry-Perot scanner. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2021, vol. 68, no. 4, p. 1007-1016. ISSN: 1525-8955.
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JAROŠ, M.; KLUSÁČEK, D.; JAROŠ, J. Optimizing Biomedical Ultrasound Workflow Scheduling Using Cluster Simulations. In Job Scheduling Strategies for Parallel Processing. JSSPP 2020. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). New Orleans: Springer Nature Switzerland AG, 2020. p. 68-84. ISBN: 978-3-030-63170-3.
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JAROŠ, M.; SASÁK, T.; TREEBY, B.; JAROŠ, J. Estimation of Execution Parameters for k-Wave Simulations. In High Performance Computing in Science and Engineering. HPCSE 2019. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Cham: Springer Nature Switzerland AG, 2021. p. 116-134. ISBN: 978-3-030-67076-4.
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BUDISKÝ, J.; TREEBY, B.; JAROŠ, J.: k-Wave-afp-omp-v1.3; k-Wave 1.3 Acoustic Field Propagator (OMP). http://www.k-wave.org/download.php. URL: http://www.k-wave.org/download.php. (software)
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JAROŠ, J.; TREEBY, B.: k-Wave-fluid-cuda-v1.3; k-Wave Toobox verze 1.3 (CUDA). http://www.k-wave.org. URL: http://www.k-wave.org. (software)
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JAROŠ, J.; TREEBY, B.; KUKLIŠ, F.; COX, B.: k-Wave-fluid-omp-v1.3; k-Wave Toobox verze 1.3 (OMP). http://www.k-wave.org. URL: http://www.k-wave.org. (software)
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JAROŠ, M.; TREEBY, B.; GEORGIOU, P.; JAROŠ, J. k-Dispatch: A Workflow Management System for the Automated Execution of Biomedical Ultrasound Simulations on Remote Computing Resources. In Proceedings of the Platform for Advanced Scientific Computing Conference, PASC 2020. New York: Association for Computing Machinery, 2020. p. 1-10. ISBN: 978-1-4503-7993-9.
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Responsibility: Jaroš Jiří, prof. Ing., Ph.D.