English

4

Not applicable.

Of all faculties

Laboratory equipment and glassware handling.
Synthesis of organic compounds in laboratory scale.
Health and safety at work in a chemical laboratory.

The knowledge of basic laboratory practices and techniques (recrystallization, distillation, extraction, etc.).

Not applicable.

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Finish 10 laboratories at least, submit lab. reports and prepared compounds during the term.
Pass test(s) about practical and theoretical knowledges.

Students are briefed by organization of laboratory and syntheses in detail during the first lab. Safety training is also realized. Students realize at least 10 syntheses of the following:
1. 2-Nitrophenol a 4-nitrophenol (1) (SEAr mechanism, steam distillation, recrystallization)
2. Ethylbromide a tert-butylchloride (2) (SN mechanism, simple distillation)
3. Ethyl acetate (3) (esterification, simple distillation)
4. Anthranilic acid (4) (Hofmann degradation of amides, recrystallization)
5. Benzoic acid and benzyl alcohol (5) (Cannizzaro reaction, extraction, vacuum distillation)
6. 2-Chlorobenzoic acid (6) (diazotation and Sandmeyer reaction, recrystallization)
7. tert-Butyl alcohol and other tertiary alcohols (12) (Grignard reagent, AN to carbonyl group, extraction, simple distillation)
8. Acetanilide (9) (acetyl derivates of amines, reflux, recrystallization)
9. Orange II (18) (diazotation and copulation, recrystallization)
10. Sulfanilic acid (4-aminobenzenesulfonic acid) (16) (SEAr mechanism, reflux, recrystallization)
11. Anhydride of cyclohex-4-ene-cis-dicarboxylic acid and Cyclohex-4-ene-cis-1,2-dicarboxylic acid (mechanism of Diels-Alder's reaction)
12. 4,4-Dimethylcyklohex-2-en-1-one (Robinson annulation, azeotropic distillation, vacuum distillation)
Labs at last week of the term are substitute for unqualified or sick students during the term.

Not applicable.

Acquisition of the basic laboratory methods of the analysis and synthesis of organic substances.

Controlled personal attendance, lab. reports a test(s).

Not applicable.

Not applicable.

Not applicable.

Sandler S.R., Karo W.: Sourcebook of Advanced Organic Laboratory Preparations. Academic Press, San Diego 1992. (EN)

78 hours, compulsory