Publication detail

Advantages and progress in the analysis of DNA by using mercury and amalgam electrodes - Review

HYNEK, D. PRÁŠEK, J. KOUDELKA, P. CHOMOUCKÁ, J. TRNKOVÁ, L. ADAM, V. HUBÁLEK, J. KIZEK, R.

Original Title

Advantages and progress in the analysis of DNA by using mercury and amalgam electrodes - Review

Type

journal article - other

Language

English

Original Abstract

The electroactivity of DNA was discovered in 1958 by Emil Palecek. Since than, there have been done great progress and development in electrochemistry of nucleic acids at various electrodes. In this review, after brief overview of milestones in research in electrochemistry, history of electroanalysis of DNA follows. Then, the attention is aimed at various electrochemical methods using a mercury electrode as a working one including linear sweep and cyclic polarography/voltammetry (elimination polarography/voltammetry), differential pulse polarography/voltammetry, square wave polarography/voltammetry, AC polarography/voltammetry and chronopotentiometry for analysis of DNA. Coupling of adsorptive transfer stripping technique to the above-mentioned methods is very promising for nucleic acid studying and is discussed. Further, advantages of mercury and amalgam electrodes are mentioned. The advantages of coupling of electroanalysis of DNA at mercury electrodes with paramagnetic particles based isolation of target molecules are shown.

Keywords

DNA, mercury electrode, DNA hybridization, nucleic acid, reduction of nucleobases, genosensors, biosensors, nanomaterials, magnetic beads, nanotechnology, automation

Authors

HYNEK, D.; PRÁŠEK, J.; KOUDELKA, P.; CHOMOUCKÁ, J.; TRNKOVÁ, L.; ADAM, V.; HUBÁLEK, J.; KIZEK, R.

RIV year

2011

Released

24. 5. 2011

Publisher

Bentham Science Publishers Ltd.

ISBN

1877-9476

Periodical

Current Physical Chemistry

Year of study

1

Number

4

State

Kingdom of the Netherlands

Pages from

299

Pages to

324

Pages count

26

BibTex

@article{BUT72550,
  author="HYNEK, D. and PRÁŠEK, J. and KOUDELKA, P. and CHOMOUCKÁ, J. and TRNKOVÁ, L. and ADAM, V. and HUBÁLEK, J. and KIZEK, R.",
  title="Advantages and progress in the analysis of DNA by using mercury and amalgam electrodes - Review",
  journal="Current Physical Chemistry",
  year="2011",
  volume="1",
  number="4",
  pages="299--324",
  issn="1877-9476"
}