Publication detail

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging

ŠURÁŇOVÁ, M. ĎURIŠ, M. ŠTENGLOVÁ NETÍKOVÁ, I. BRÁBEK, J. HORÁK, T. JŮZOVÁ, V. CHMELÍK, R. VESELÝ, P.

Original Title

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging

Type

journal article in Web of Science

Language

English

Original Abstract

Solid tumor metastases cause most cancer-related deaths. The prevention of their occurrence misses suitable anti-metastases medicines newly labeled as migrastatics. The first indication of migrastatics potential is based on an inhibition of in vitro enhanced migration of tumor cell lines. Therefore, we decided to develop a rapid test for qualifying the expected migrastatic potential of some drugs for repurposing. The chosen Q-PHASE holographic microscope provides reliable multifield time-lapse recording and simultaneous analysis of the cell morphology, migration, and growth. The results of the pilot assessment of the migrastatic potential exerted by the chosen medicines on selected cell lines are presented.

Keywords

In-vitro; Multi-field; Quantitative phase imaging; Rapid test; Repurposing; Simultaneous analysis; Solid tumors; Time-lapse recording; Tumor cell lines; Tumor metastasis

Authors

ŠURÁŇOVÁ, M.; ĎURIŠ, M.; ŠTENGLOVÁ NETÍKOVÁ, I.; BRÁBEK, J.; HORÁK, T.; JŮZOVÁ, V.; CHMELÍK, R.; VESELÝ, P.

Released

1. 6. 2023

Publisher

Optica

ISBN

2156-7085

Periodical

Biomedical Optics Express

Year of study

14

Number

6

State

United States of America

Pages from

2689

Pages to

2708

Pages count

20

URL

https://opg.optica.org/boe/fulltext.cfm?uri=boe-14-6-2689&id=530666

Full text in the Digital Library

http://hdl.handle.net/11012/213614

BibTex

@article{BUT183847,
  author="Markéta {Šuráňová} and Miroslav {Ďuriš} and Irena {Štenglová Netíková} and Jan {Brábek} and Tomáš {Horák} and Veronika {Jůzová} and Radim {Chmelík} and Pavel {Veselý}",
  title="Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging",
  journal="Biomedical Optics Express",
  year="2023",
  volume="14",
  number="6",
  pages="2689--2708",
  doi="10.1364/BOE.488630",
  issn="2156-7085",
  url="https://opg.optica.org/boe/fulltext.cfm?uri=boe-14-6-2689&id=530666"
}