Publication detail

A Pilot Study on the Functional Stability of Phonation in EEG Bands After Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

GÓMEZ-RODELLAR, A. MEKYSKA, J. GOMEZ-VILDA, P. BRABENEC, L. ŠIMKO, P. REKTOROVÁ, I.

Original Title

A Pilot Study on the Functional Stability of Phonation in EEG Bands After Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

Type

journal article in Web of Science

Language

English

Original Abstract

Parkinson's disease (PD) is a neurodegenerative condition with constantly increasing prevalence rates, affecting strongly life quality in terms of neuromotor and cognitive performance. PD symptoms include voice and speech alterations, known as hypokinetic dysarthria (HD). Unstable phonation is one of the manifestations of HD. Repetitive transcranial magnetic stimulation (rTMS) is a rehabilitative treatment thathas been shown to improve some motor and non-motor symptoms of persons with PD (PwP). This study analyzed the phonation functional behavior of 18 participants (13 males, 5 females) with PD diagnosis before (one pre-stimulus) and after (four post-stimulus) evaluation sessions of rTMS treatment, to assess the extent of changes in their phonation stability. Participants were randomized 1:1 to receive either rTMS or sham stimulation. Voice recordings of a sustained vowel [a:] taken immediately before and after the treatment, and at follow-up evaluation sessions (immediately after, at six, ten, and fourteen weeks after the baseline assessment) were processed by inverse filtering to estimate a biomechanical correlate of vocal fold tension. This estimate was further band-pass filtered into EEG-related frequency bands. Log-likelihood ratios (LLRs) between pre- and post-stimulus amplitude distributions of each frequency band showed significant differences in five cases actively stimulated. Seven cases submitted to the sham protocol did not show relevant improvements in phonation instability. Conversely, four active cases did not show phonation improvements, whereas two sham cases did. The study provides early preliminary insights into the capability of phonation quality assessment by monitoring neuromechanical activity from acoustic signals in frequency bands aligned with EEG ones.

Keywords

Parkinson's disease; functional quality assessment of phonation; acoustical EEG activity monitoring; repetitive transcranial magnetic stimulation

Authors

GÓMEZ-RODELLAR, A.; MEKYSKA, J.; GOMEZ-VILDA, P.; BRABENEC, L.; ŠIMKO, P.; REKTOROVÁ, I.

Released

1. 5. 2023

Publisher

WORLD SCIENTIFIC PUBL CO PTE LTD

Location

SINGAPORE

ISBN

0129-0657

Periodical

INTERNATIONAL JOURNAL OF NEURAL SYSTEMS

Year of study

33

Number

6

State

United States of America

Pages count

21

URL

https://pubmed.ncbi.nlm.nih.gov/37118909/

BibTex

@article{BUT183606,
  author="Andrés {Gómez-Rodellar} and Jiří {Mekyska} and Pedro {Gomez-Vilda} and Luboš {Brabenec} and Patrik {Šimko} and Irena {Rektorová}",
  title="A Pilot Study on the Functional Stability of Phonation in EEG Bands After Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease",
  journal="INTERNATIONAL JOURNAL OF NEURAL SYSTEMS",
  year="2023",
  volume="33",
  number="6",
  pages="21",
  doi="10.1142/S0129065723500284",
  issn="0129-0657",
  url="https://pubmed.ncbi.nlm.nih.gov/37118909/"
}