Publication detail

On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems

SLANINOVÁ, E. OBRUČA, S. KOCHERBITOV, V. SEDLÁČEK, P.

Original Title

On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems

Type

journal article in Web of Science

Language

English

Original Abstract

The comprehensive study of the phase behavior of sodium 3-hydroxybutyrate (Na3HB) in aqueous mixtures has shed new light on the recently revealed bioprotective role of this compound in poly(3-hydroxybutyrate)-accumulating microorganisms. The outstandingly hydrophilic nature of 3HB is shown, which is comparable with, but in some perspectives (solubility, water activity decreased in solution) even better than some well-recognized compatible solutes such as trehalose. This is of crucial importance also from the view of its potential application in the technological fields in which stabilization of biological molecules is required (e.g., cryopreservation, food preservation, cosmetics). The study also revealed that 3HB can form, depending on the conditions, at least two different crystalline forms: anhydrous crystal and crystalline dihydrates.

Keywords

3-hydroxybutyrate;cryoprotectant;binary phase diagram;Na3HB/water system

Authors

SLANINOVÁ, E.; OBRUČA, S.; KOCHERBITOV, V.; SEDLÁČEK, P.

Released

7. 2. 2023

Publisher

Biophysical Society

ISBN

0006-3495

Periodical

BIOPHYSICAL JOURNAL

Year of study

122

Number

3

State

United States of America

Pages from

460

Pages to

469

Pages count

10

URL

https://www.sciencedirect.com/science/article/pii/S0006349523000048

Full text in the Digital Library

http://hdl.handle.net/11012/209157

BibTex

@article{BUT182919,
  author="Eva {Slaninová} and Stanislav {Obruča} and Vitaly {Kocherbitov} and Petr {Sedláček}",
  title="On the bioprotective effects of 3-hydroxybutyrate: Thermodynamic study of binary 3HB-water systems",
  journal="BIOPHYSICAL JOURNAL",
  year="2023",
  volume="122",
  number="3",
  pages="460--469",
  doi="10.1016/j.bpj.2023.01.004",
  issn="0006-3495",
  url="https://www.sciencedirect.com/science/article/pii/S0006349523000048"
}