Publication detail

Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice

Solovieva, AO. Permyakova, ES. Ershov, KI. Bakhareva, KI. Miroshnichenko, SM. Kiryukhantsev-Korneev, PV. Konopatsky, AS. Polcak, J. Shtansky, DV. Manakhov, AM

Original Title

Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice

Type

journal article in Web of Science

Language

English

Original Abstract

COOH plasma polymer layers deposited onto polycaprolactone (PCL) nanofibers by plasma polymerization of CO2 and C2H4 in the Ar atmosphere were obtained and tested for diabetic wound healing. Simply by changing the deposition time, very different morphologies of coated PCL nanofibers were achieved. In vivo tests revealed that by applying modified nanofibers for 10 days, wound healing accelerated by 32.1%. Compared to a controlled wound characterized by an acute inflammatory process, wounds covered with nanofibers with platelet-rich plasma demonstrated complete healing with a high percentage of collagen fibers on Day 19.

Keywords

in vivo; polycaprolactone; type 2 diabetes mellitus; wound healing; XPS

Authors

Solovieva, AO.; Permyakova, ES.; Ershov, KI.; Bakhareva, KI.; Miroshnichenko, SM.; Kiryukhantsev-Korneev, PV.; Konopatsky, AS.; Polcak, J.; Shtansky, DV.; Manakhov, AM

Released

1. 7. 2022

ISBN

1612-8869

Periodical

Plasma Processes and Polymers

Year of study

19

Number

7

State

Federal Republic of Germany

Pages from

e2200032

Pages count

12

URL

https://onlinelibrary.wiley.com/doi/10.1002/ppap.202200032

BibTex

@article{BUT178560,
  author="Solovieva, AO. and Permyakova, ES. and Ershov, KI. and Bakhareva, KI. and Miroshnichenko, SM. and Kiryukhantsev-Korneev, PV. and Konopatsky, AS. and Polcak, J. and Shtansky, DV. and Manakhov, AM",
  title="Plasma-coated PCL scaffolds with immobilized platelet-rich plasma enhance the wound healing in diabetics mice",
  journal="Plasma Processes and Polymers",
  year="2022",
  volume="19",
  number="7",
  pages="12",
  doi="10.1002/ppap.202200032",
  issn="1612-8869",
  url="https://onlinelibrary.wiley.com/doi/10.1002/ppap.202200032"
}