Publication detail

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

GOMEZ PEREZ, I. RUSSO, M. ARCIDIACONO, O. MARQUEZ SANCHEZ - CARNERERO, E. KLÁN, P. ZAJÍČKOVÁ, L.

Original Title

Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

Type

journal article in Web of Science

Language

English

Original Abstract

The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.

Keywords

SINGLET OXYGEN GENERATION; PHOTODYNAMIC THERAPY; CARBON DOTS; NANOPARTICLES; DERIVATIVES; MECHANISMS; MOLECULES

Authors

GOMEZ PEREZ, I.; RUSSO, M.; ARCIDIACONO, O.; MARQUEZ SANCHEZ - CARNERERO, E.; KLÁN, P.; ZAJÍČKOVÁ, L.

Released

13. 6. 2022

Publisher

ROYAL SOC CHEMISTRY

Location

CAMBRIDGE

ISBN

2052-1537

Periodical

MATERIALS CHEMISTRY FRONTIERS

Year of study

6

Number

12

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1719

Pages to

1726

Pages count

8

URL

https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K

BibTex

@article{BUT178464,
  author="Inmaculada Jennifer {Gomez Perez} and Marina {Russo} and Orazio Angelo {Arcidiacono} and Esther Maria {Marquez Sanchez - Carnerero} and Petr {Klán} and Lenka {Zajíčková}",
  title="Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers",
  journal="MATERIALS CHEMISTRY FRONTIERS",
  year="2022",
  volume="6",
  number="12",
  pages="1719--1726",
  doi="10.1039/d2qm00200k",
  issn="2052-1537",
  url="https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K"
}