Publication detail

Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis

VOJTOVÁ, L. MICHLOVSKÁ, L. GRÉZLOVÁ, V. DORAZILOVÁ, J. ŠMERKOVÁ, K. KOPEL, P. ADAM, V. HLINÁKOVÁ, K. DIVIŠ, P. LUKÁŠOVÁ, V. RAMPICHOVÁ, M. SUCHÝ, T. BARTOŠ, M. SEDLÁČEK, R. BALLAY, R. MELICHERČÍK, P. KLAPKOVÁ, E. VIŠTEJNOVÁ, L. KLEIN, P.

Original Title

Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis

Type

abstract

Language

English

Original Abstract

All surgeries carry the risk of complications due to bacterial infections. Infected hip or knee revisions are generally accompanied with local and systemic antibiotic therapy. Generally, in two-stage revisions, non- degradable poly(methyl methacrylate) spacers loaded with antibiotics are used. Only 3-5% of the antibiotic appears to be released during in vivo testing. To overcome this issue, we have developed a biodegradable, “self- setting”, thixotropic and osteoconductive bone cement based on polymer and calcium phosphate. In the presented work, we loaded the cement with either vancomycin or biogenic selenium nanoparticles (SeNPs) to compare their release and antimicrobial efficiency in vitro.

Keywords

calcium phosphate, bone cement, biodegradable, self-setting, antibiotic, vancomycin, selenium nanoparticles, release, in vivo, in vitro

Authors

VOJTOVÁ, L.; MICHLOVSKÁ, L.; GRÉZLOVÁ, V.; DORAZILOVÁ, J.; ŠMERKOVÁ, K.; KOPEL, P.; ADAM, V.; HLINÁKOVÁ, K.; DIVIŠ, P.; LUKÁŠOVÁ, V.; RAMPICHOVÁ, M.; SUCHÝ, T.; BARTOŠ, M.; SEDLÁČEK, R.; BALLAY, R.; MELICHERČÍK, P.; KLAPKOVÁ, E.; VIŠTEJNOVÁ, L.; KLEIN, P.

Released

14. 6. 2021

Publisher

eCM Meeting Abstracts

ISBN

2522-235X

Periodical

eCM Periodical

Year of study

2021

Number

1

State

Swiss Confederation

Pages from

21

Pages to

21

Pages count

1

URL

https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html

BibTex

@misc{BUT175280,
  author="Lucy {Vojtová} and Lenka {Michlovská} and Veronika {Grézlová} and Jana {Dorazilová} and Kristýna {Šmerková} and Pavel {Kopel} and Vojtěch {Adam} and Kristýna {Hlináková} and Pavel {Diviš} and Věra {Lukášová} and Michaela {Rampichová} and Tomáš {Suchý} and Martin {Bartoš} and Radek {Sedláček} and Rastislav {Ballay} and Pavel {Melicherčík} and Eva {Klapková} and Lucie {Vištejnová} and Pavel {Klein}",
  title="Efficacy of Various Antimicrobial Agents Loaded in Resorbable Porous Bone Cement Useful in the Treatment of Osteomyelitis",
  year="2021",
  journal="eCM Periodical",
  volume="2021",
  number="1",
  pages="21--21",
  publisher="eCM Meeting Abstracts",
  issn="2522-235X",
  url="https://www.ecmconferences.org/abstracts/2021/Collection1/c1.html",
  note="abstract"
}