Publication detail

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

CHYRÁ, Z. ŠEVČÍKOVÁ, T. VOJTA, P. PUTEROVÁ, J. BROŽOVÁ, L. GROWKOVÁ, K. FILIPOVÁ, J. ZÁTOPKOVÁ, M. GROSICKI, S. BARCHANICKA, A. JĘDRZEJCZAK, W. WASZCZUK-GAJDA, A. JUNGOVÁ, A. MIKULÁŠOVÁ, A. HAJDÚCH, M. MOKREJŠ, M. POUR, L. ŠTORK, M. HARVANOVÁ, Ľ. MISTRÍK, M. MIKALA, G. ROBAK, P. CZYŻ, A. DĘBSKI, J. USNARSKA-ZUBKIEWICZ, L. JURCZYSZYN, A. STEJSKAL, L. MORGAN, G. KRYUKOV, F. BUDINSKÁ, E. ŠIMÍČEK, M. JELÍNEK, T. HRDINKA, M. HÁJEK, R.

Original Title

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

Type

journal article in Web of Science

Language

English

Original Abstract

We aim to provide the very first insight into ALA (amyloidosis) +MM (multiple myeloma) molecular profiles and compare the results with ALA and with MM. Our detailed study of ALA and ALA+MM represents an important step towards the improved understanding of their genetic and transcriptomic background, which is a prerequisite for the development of optimal treatment strategies in the future.

Keywords

amyloidosis, multiple myeloma, clonality, cancer

Authors

CHYRÁ, Z.; ŠEVČÍKOVÁ, T.; VOJTA, P.; PUTEROVÁ, J.; BROŽOVÁ, L.; GROWKOVÁ, K.; FILIPOVÁ, J.; ZÁTOPKOVÁ, M.; GROSICKI, S.; BARCHANICKA, A.; JĘDRZEJCZAK, W.; WASZCZUK-GAJDA, A.; JUNGOVÁ, A.; MIKULÁŠOVÁ, A.; HAJDÚCH, M.; MOKREJŠ, M.; POUR, L.; ŠTORK, M.; HARVANOVÁ, Ľ.; MISTRÍK, M.; MIKALA, G.; ROBAK, P.; CZYŻ, A.; DĘBSKI, J.; USNARSKA-ZUBKIEWICZ, L.; JURCZYSZYN, A.; STEJSKAL, L.; MORGAN, G.; KRYUKOV, F.; BUDINSKÁ, E.; ŠIMÍČEK, M.; JELÍNEK, T.; HRDINKA, M.; HÁJEK, R.

Released

6. 2. 2021

ISBN

1592-8721

Periodical

Haematologica

Year of study

106

Number

2

State

Republic of Italy

Pages from

601

Pages to

604

Pages count

4

URL

https://haematologica.org/article/view/9744

BibTex

@article{BUT168529,
  author="CHYRÁ, Z. and ŠEVČÍKOVÁ, T. and VOJTA, P. and PUTEROVÁ, J. and BROŽOVÁ, L. and GROWKOVÁ, K. and FILIPOVÁ, J. and ZÁTOPKOVÁ, M. and GROSICKI, S. and BARCHANICKA, A. and JĘDRZEJCZAK, W. and WASZCZUK-GAJDA, A. and JUNGOVÁ, A. and MIKULÁŠOVÁ, A. and HAJDÚCH, M. and MOKREJŠ, M. and POUR, L. and ŠTORK, M. and HARVANOVÁ, Ľ. and MISTRÍK, M. and MIKALA, G. and ROBAK, P. and CZYŻ, A. and DĘBSKI, J. and USNARSKA-ZUBKIEWICZ, L. and JURCZYSZYN, A. and STEJSKAL, L. and MORGAN, G. and KRYUKOV, F. and BUDINSKÁ, E. and ŠIMÍČEK, M. and JELÍNEK, T. and HRDINKA, M. and HÁJEK, R.",
  title="Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis",
  journal="Haematologica",
  year="2021",
  volume="106",
  number="2",
  pages="601--604",
  doi="10.3324/haematol.2019.239756",
  issn="1592-8721",
  url="https://haematologica.org/article/view/9744"
}