Publication detail

Glutathione modified CdTe quantum dots as a label for studying DNA interactions with platinum based cytostatics

VACULOVIČOVÁ, M. ŠMERKOVÁ, K. PEKÁRKOVÁ, J. HUBÁLEK, J. ADAM, V. KIZEK, R.

Original Title

Glutathione modified CdTe quantum dots as a label for studying DNA interactions with platinum based cytostatics

Type

journal article in Web of Science

Language

English

Original Abstract

Cisplatin, carboplatin, and oxaliplatin represent three generations of platinum based drugs applied successfully for cancer treatment. As a consequence of the employment of platinum based cytostatics in the cancer treatment, it became necessary to study the mechanism of their action. Current accepted opinion is the formation of Pt-DNA adducts, but the mechanism of their formation is still unclear. Nanomaterials, as a progressively developing branch, can offer a tool for studying the interactions of these drugs with DNA

Keywords

Capillary electrophoresis, DNA, Gel electrophoresis, Platinum cytostatic drugs, Quantum dots

Authors

VACULOVIČOVÁ, M.; ŠMERKOVÁ, K.; PEKÁRKOVÁ, J.; HUBÁLEK, J.; ADAM, V.; KIZEK, R.

RIV year

2013

Released

1. 3. 2013

Publisher

Wiley

Location

Německo

ISBN

0173-0835

Periodical

Electrophoresis

Year of study

34

Number

6

State

Federal Republic of Germany

Pages from

801

Pages to

808

Pages count

8

BibTex

@article{BUT100726,
  author="Markéta {Vaculovičová} and Kristýna {Šmerková} and Jana {Pekárková} and Jaromír {Hubálek} and Vojtěch {Adam} and René {Kizek}",
  title="Glutathione modified CdTe quantum dots as a label for studying DNA interactions with platinum based cytostatics",
  journal="Electrophoresis",
  year="2013",
  volume="34",
  number="6",
  pages="801--808",
  doi="10.1002/elps.201200664",
  issn="0173-0835"
}