Publication detail

Biodegradable Thermoplastic Starch/Polycaprolactone Blends with Co-Continuous Morphology Suitable for Local Release of Antibiotics

GAJDOŠOVÁ, V. STRACHOTA, B. STRACHOTA, A. MICHÁLKOVÁ, D.KREJČÍKOVÁ, S. FULIN, P. NYC, O. BŘÍNEK, A. ZEMEK, M. ŠLOUF, M.

Original Title

Biodegradable Thermoplastic Starch/Polycaprolactone Blends with Co-Continuous Morphology Suitable for Local Release of Antibiotics

Type

journal article in Web of Science

Language

English

Original Abstract

We report a reproducible preparation and characterization of highly homogeneous thermoplastic starch/pol(epsilon-caprolactone) blends (TPS/PCL) with a minimal thermomechanical degradation and co-continuous morphology. These materials would be suitable for biomedical applications, specifically for the local release of antibiotics (ATB) from the TPS phase. The TPS/PCL blends were prepared in the whole concentration range. In agreement with theoretical predictions based on component viscosities, the co-continuous morphology was found for TPS/PCL blends with a composition of 70/30 wt.%. The minimal thermomechanical degradation of the blends was achieved by an optimization of the processing conditions and by keeping processing temperatures as low as possible, because higher temperatures might damage ATB in the final application. The blends' homogeneity was verified by scanning electron microscopy. The co-continuous morphology was confirmed by submicron-computed tomography. The mechanical performance of the blends was characterized in both microscale (by an instrumented microindentation hardness testing; MHI) and macroscale (by dynamic thermomechanical analysis; DMTA). The elastic moduli of TPS increased ca four times in the TPS/PCL (70/30) blend. The correlations between elastic moduli measured by MHI and DMTA were very strong, which implied that, in the future studies, it would be possible to use just micromechanical testing that does not require large specimens.

Keywords

thermoplastic starch; poly(epsilon-caprolactone); polymer blends; micromechanical properties; microindentation; structure-properties relations

Authors

GAJDOŠOVÁ, V.; STRACHOTA, B.; STRACHOTA, A.; MICHÁLKOVÁ, D.;KREJČÍKOVÁ, S.; FULIN, P.; NYC, O.; BŘÍNEK, A.; ZEMEK, M.; ŠLOUF, M.

Released

30. 1. 2022

Publisher

MDPI

Location

BASEL

ISBN

1996-1944

Periodical

Materials

Year of study

15

Number

3

State

Swiss Confederation

Pages from

1

Pages to

22

Pages count

22

URL

https://www.mdpi.com/1996-1944/15/3/1101

Full text in the Digital Library

http://hdl.handle.net/11012/204576

BibTex

@article{BUT177480,
  author="Veronika {Gajdošová} and Beata {Strachota} and Adam {Strachota} and Danuše {Michálková} and Sabina {Krejčíková} and Petr {Fulin} and Otakar {Nyč} and Adam {Břínek} and Marek {Zemek} and Miroslav {Šlouf}",
  title="Biodegradable Thermoplastic Starch/Polycaprolactone Blends with Co-Continuous Morphology Suitable for Local Release of Antibiotics",
  journal="Materials",
  year="2022",
  volume="15",
  number="3",
  pages="1--22",
  doi="10.3390/ma15031101",
  issn="1996-1944",
  url="https://www.mdpi.com/1996-1944/15/3/1101"
}