Publication detail

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

GREGG, N. SLADKÝ, V. NEJEDLÝ, P. MÍVALT, F. KIM, I. BALZEKAS, I. STURGES, B. CROWE, C. PATTERSON, E. VAN GOMPEL, J. LUNDSTROM, B. LEYDE, K. DENISON, T. BRINKMANN, B. KŘEMEN, V. WORRELL, G.

Original Title

Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

Type

journal article in Web of Science

Language

English

Original Abstract

Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.

Keywords

epilepsy; DBS; long term trends; neuromodulation

Authors

GREGG, N.; SLADKÝ, V.; NEJEDLÝ, P.; MÍVALT, F.; KIM, I.; BALZEKAS, I.; STURGES, B.; CROWE, C.; PATTERSON, E.; VAN GOMPEL, J.; LUNDSTROM, B.; LEYDE, K.; DENISON, T.; BRINKMANN, B.; KŘEMEN, V.; WORRELL, G.

Released

20. 12. 2021

Publisher

Springer Nature

Location

BERLIN

ISBN

2045-2322

Periodical

Scientific Reports

Year of study

11

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

12

Pages count

12

URL

https://www.nature.com/articles/s41598-021-03555-7

Full text in the Digital Library

http://hdl.handle.net/11012/203997

BibTex

@article{BUT176543,
  author="Nicholas M. {Gregg} and Vladimír {Sladký} and Petr {Nejedlý} and Filip {Mívalt} and Inyong {Kim} and Irena {Balzekas} and Beverly K {Sturges} and Chelsea M {Crowe} and Edward E. {Patterson} and Jamie J. {Van Gompel} and Brian {Lundstrom} and Kent {Leyde} and Timothy {Denison} and Benjamin H. {Brinkmann} and Václav {Křemen} and Gregory {Worrell}",
  title="Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy",
  journal="Scientific Reports",
  year="2021",
  volume="11",
  number="1",
  pages="1--12",
  doi="10.1038/s41598-021-03555-7",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-021-03555-7"
}