Publication detail

Characteristic Waveforms for Testing of Medical Aerosol Inhalers

PAŠTĚKA, R. FORJAN, M. SANTOS, P.

Original Title

Characteristic Waveforms for Testing of Medical Aerosol Inhalers

Type

conference paper

Language

English

Original Abstract

Respiratory diseases are characterised by high prevalence among the European population. Medical aerosol inhalers are the most commonly used means of drug delivery into the human respiratory system. This paper focuses on characteristic waveforms that can be utilised during aerosol deposition studies to simulate conditions of rapid human inhalation. Additionally, an inhalatory waveform based on clinically recorded spirometry data is introduced. Experimental measurements are performed and simulation results mutually compared using the electro-mechanical lung simulator xPULM™. The inhalatory waveforms are repeatably simulated with high fidelity in regards to the waveform shape with the lowest value of the Goodness of fit 0.89. Additionally, the measured values for all characteristic inhalatory parameters are simulated with low standard deviation σ < 1. The differences between the required and measured waveform shapes are small, ΔPIF < 3 L/min and do not influence the overall inhalatory volume. This opens a possibility of utilising the xPULM for medical aerosol inhalers testing.

Keywords

Inhalatory waveforms, medical aerosol inhalers, electro-mechanical lung simulator, medical device testing

Authors

PAŠTĚKA, R.; FORJAN, M.; SANTOS, P.

Released

20. 12. 2020

Publisher

Springer Science and Business Media Deutschland GmbH

ISBN

978-3-030-64609-7

Book

8th European Medical and Biological Engineering Conference

Edition

EMBEC2020

Edition number

80

ISBN

1680-0737

Periodical

IFMBE PROCEEDINGS

Year of study

80

State

Kingdom of Sweden

Pages from

240

Pages to

246

Pages count

6

URL

https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550

BibTex

@inproceedings{BUT172369,
  author="Richard {Paštěka} and Mathias {Forjan} and Pedro {Santos}",
  title="Characteristic Waveforms for Testing of Medical Aerosol Inhalers",
  booktitle="8th European Medical and Biological Engineering Conference",
  year="2020",
  series="EMBEC2020",
  journal="IFMBE PROCEEDINGS",
  volume="80",
  number="80",
  pages="240--246",
  publisher="Springer Science and Business Media Deutschland GmbH",
  doi="10.1007/978-3-030-64610-3\{_}28",
  isbn="978-3-030-64609-7",
  issn="1680-0737",
  url="https://www.springerprofessional.de/en/characteristic-waveforms-for-testing-of-medical-aerosol-inhalers/18638550"
}