Publication detail

TEST OF COMPLEX NANOSTRUCTURES AS GENE DELIVERY SYSTEM TO CARDIAC CELLS

SKOPALÍK, J. PRŮCHA, J. SEKORA, J. ČMIEL, V. PARAK, T. MASEK, j.

Original Title

TEST OF COMPLEX NANOSTRUCTURES AS GENE DELIVERY SYSTEM TO CARDIAC CELLS

Type

conference paper

Language

English

Original Abstract

Various nanostructures, including liposomes, dendrimers, polymers, carbon or silicon materials, and metal nanoparticles seems to be evaluated as carriers in different gene delivery systems. Muscle cells are target of modern gene medicine, due to of the much pathology (arrhythmias, channels pathological mutation, abnormal apoptosis) with limited curability by traditional drugs. The zeta potential of the muscle cells were identified by non-traditional method of DLS. This was starting point to setting of parameters for experimental liposome, the liposome surface charge have been tested and modified by cationic plasmid and final complex was evaluated as delivery system of DNA into the muscle cardiac cells.

Keywords

Nanoliposom; nanoparticle; transfection; zeta potential; cell engineering; regenerative medicine

Authors

SKOPALÍK, J.; PRŮCHA, J.; SEKORA, J.; ČMIEL, V.; PARAK, T.; MASEK, j.

Released

28. 12. 2020

Publisher

TANGER LTD

Location

SLEZSKA

ISBN

978-80-87294-98-7

Book

NANOCON

Pages from

342

Pages to

346

Pages count

5

BibTex

@inproceedings{BUT166063,
  author="SKOPALÍK, J. and PRŮCHA, J. and SEKORA, J. and ČMIEL, V. and PARAK, T. and MASEK, j.",
  title="TEST OF COMPLEX NANOSTRUCTURES AS GENE DELIVERY SYSTEM TO CARDIAC CELLS",
  booktitle="NANOCON",
  year="2020",
  pages="342--346",
  publisher="TANGER LTD",
  address="SLEZSKA",
  doi="10.37904/nanocon.2020.3757",
  isbn="978-80-87294-98-7"
}