Detail publikace

Mammalian metallothioneins: properties and functions

BABULA, P. MASAŘÍK, M. ADAM, V. ECKSCHLAGER, T. STIBOROVÁ, M. TRNKOVÁ, L. ŠKUTKOVÁ, H. PROVAZNÍK, I. HUBÁLEK, J. KIZEK, R.

Originální název

Mammalian metallothioneins: properties and functions

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their afinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective efects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc( II ) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a ossible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

Klíčová slova

metallothionein, cell proliferation, free radicals

Autoři

BABULA, P.; MASAŘÍK, M.; ADAM, V.; ECKSCHLAGER, T.; STIBOROVÁ, M.; TRNKOVÁ, L.; ŠKUTKOVÁ, H.; PROVAZNÍK, I.; HUBÁLEK, J.; KIZEK, R.

Rok RIV

2012

Vydáno

1. 8. 2012

Nakladatel

Royal Society of Chemistry

Místo

UK

ISSN

1756-5901

Periodikum

METALLOMICS

Ročník

4

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

739

Strany do

750

Strany počet

12

BibTex

@article{BUT93281,
  author="Petr {Babula} and Michal {Masařík} and Vojtěch {Adam} and Tomáš {Eckschlager} and Marie {Stiborová} and Libuše {Trnková} and Helena {Vítková} and Valentine {Provazník} and Jaromír {Hubálek} and René {Kizek}",
  title="Mammalian metallothioneins: properties and functions",
  journal="METALLOMICS",
  year="2012",
  volume="4",
  number="1",
  pages="739--750",
  doi="10.1039/c2mt20081c",
  issn="1756-5901"
}