Detail publikačního výsledku

I/D ACE gene polymorphism in survival of leukemia patients - hypothesis and pilot study

HÁJEK, D.; TOMISKA, M.; KRAHULCOVÁ, E.; DRUCKMÜLLER, M.; FLORIÁNOVÁ, M.; IZAKOVIČOVÁ-HOLLÁ, L.; VÁCHA, J.

Originální název

I/D ACE gene polymorphism in survival of leukemia patients - hypothesis and pilot study

Anglický název

I/D ACE gene polymorphism in survival of leukemia patients - hypothesis and pilot study

Druh

Článek recenzovaný mimo WoS a Scopus

Originální abstrakt

Angiotensin-I converting enzyme (ACE) is involved not only in intracellular volume regulation but also in proliferation control. Since both ACE gene polymorphism (I/D ACE) and ABO blood group determine ACE level in peripheral blood and probably also in bone marrow, the hypothesis to the interindividual differences in survival of leukemic patients was suggested.The data of 25 patients of both sexes with acute myelogenous (AML), acute lymphatic (ALL), chronic myelogenous (CML) and chronic lymphatic (CLL) leukemia treated by conventional were used for the study.The overall survival (SUR) was estimated as the time from the date of diagnosis to the date of death. The difference between patient's individual SUR (iSUR) and median SUR according to the type of leukemia (mSUR) was calculated. This difference (iSUR-mSUR) varied with I/D ACE genotype (p<0.02) but neither with diagnosis nor with ABO blood group. The regression model for iSUR calculation, from mSUR and I/D ACE genotype, has been suggested.

Anglický abstrakt

Angiotensin-I converting enzyme (ACE) is involved not only in intracellular volume regulation but also in proliferation control. Since both ACE gene polymorphism (I/D ACE) and ABO blood group determine ACE level in peripheral blood and probably also in bone marrow, the hypothesis to the interindividual differences in survival of leukemic patients was suggested.The data of 25 patients of both sexes with acute myelogenous (AML), acute lymphatic (ALL), chronic myelogenous (CML) and chronic lymphatic (CLL) leukemia treated by conventional were used for the study.The overall survival (SUR) was estimated as the time from the date of diagnosis to the date of death. The difference between patient's individual SUR (iSUR) and median SUR according to the type of leukemia (mSUR) was calculated. This difference (iSUR-mSUR) varied with I/D ACE genotype (p<0.02) but neither with diagnosis nor with ABO blood group. The regression model for iSUR calculation, from mSUR and I/D ACE genotype, has been suggested.

Klíčová slova

chronic lymphatic leukemia

Klíčová slova v angličtině

chronic lymphatic leukemia

Autoři

HÁJEK, D.; TOMISKA, M.; KRAHULCOVÁ, E.; DRUCKMÜLLER, M.; FLORIÁNOVÁ, M.; IZAKOVIČOVÁ-HOLLÁ, L.; VÁCHA, J.

Vydáno

01.07.2003

Nakladatel

Elsevier

Místo

Spojené království

ISSN

0306-9877

Periodikum

MEDICAL HYPOTHESES

Svazek

2003

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

80

Strany počet

5

URL

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12781647&dopt=Abstract

BibTex

@article{BUT43808,
  author="Dobroslav {Hájek} and Miroslav {Tomiska} and Eva {Krahulcová} and Miloslav {Druckmüller} and Marie {Floriánová} and Ludmila {Izakovičová-Hollá} and Jan {Vácha}",
  title="I/D ACE gene polymorphism in survival of leukemia patients - hypothesis and pilot study",
  journal="MEDICAL HYPOTHESES",
  year="2003",
  volume="2003",
  number="1",
  pages="5",
  issn="0306-9877",
  url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12781647&dopt=Abstract"
}